10315-06-7Relevant articles and documents
Discriminating non-ylidic carbon-sulfur bond cleavages of sulfonium ylides for alkylation and arylation reactions
Fang, Jing,Li, Ting,Ma, Xiang,Sun, Jiuchang,Cai, Lei,Chen, Qi,Liao, Zhiwen,Meng, Lingkui,Zeng, Jing,Wan, Qian
, p. 288 - 292 (2021/07/25)
A sulfonium ylide participated alkylation and arylation under transition-metal free conditions is described. The disparate reaction pattern allowed the separate activation of non-ylidic S-alkyl and S-aryl bond. Under acidic conditions, sulfonium ylides serve as alkyl cation precursors which facilitate the alkylations. While under alkaline conditions, cleavage of non-ylidic S-aryl bond produces O-arylated compounds efficiently. The robustness of the protocols were established by the excellent compatibility of wide variety of substrates including carbohydrates.
Production process of N-benzyl-4-methyl isonipecotate
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Paragraph 0022; 0023; 0024; 0025, (2018/05/01)
The invention belongs to the technical field of pharmaceutical chemicals, and concretely relates to a production process of N-benzyl-4-methyl isonipecotate. The process comprises the following steps of reacting 4-methyl isonipecotate and benzyl chloride in a reaction solvent under an acid-binding agent condition, cooling after finishing raw material reaction, adding water for washing, drying and filtering an organic layer, and concentrating to obtain the N-benzyl-4-methyl isonipecotate. According to the process, 1,2-dichloroethane is adopted as a solvent for reaction, and the 1,2-dichloroethane obtained through concentration can be recycled, so that an environment-friendly performance is realized, and the raw material cost is greatly reduced.
Preparation method of 1-benzyl-4-piperidine formaldehyde
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Paragraph 0040; 0041; 0042; 0043, (2016/10/08)
The invention discloses a preparation method of 1-benzyl-4-piperidine formaldehyde. The preparation method comprises the following steps of carrying out a partial reduction reaction on 1-benzyl-4-piperidine methyl formate or 1-benzyl-4-piperidine ethyl formate and a vitride complex in a solvent; then collecting the 1-benzyl-4-piperidine formaldehyde from a reaction product. According to the preparation method of the 1-benzyl-4-piperidine formaldehyde, disclosed by the invention, 1-benzyl-4-piperidine formic acid esters are used as raw materials, the vitride complex is used as a reducing agent, the raw materials are easy to prepare, the operation is simple and convenient, the yield is high, the product purity is good, and the preparation method is suitable for industrial production.