8-ethyl 8-Methyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate

Base Information

• Chemical Name: 8-ethyl 8-Methyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate
• CAS No.: 340022-79-9
• Molecular Formula: C₁₃H₂₀O₆
• Molecular Weight: 272.298
• Hs Code.: 2932999099
• Mol file: 340022-79-9.mol

Synonyms:8-ethyl 8-Methyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate

Chemical Property of 8-ethyl 8-Methyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate

Chemical Property:

• PSA: 71.06000
• LogP: 1.02600
• Storage Temp.: 2-8°C

Purity/Quality:

Dimethyl1,4-dioxaspiro-[4.5]decane-8,8-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-ethyl 8-Methyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate

There total 2 articles about 8-ethyl 8-Methyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate (1489-97-0) + carbonic acid dimethyl ester (616-38-6) → 8-ethyl 8-methyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate (340022-79-9)

Guidance literature:

ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

carbonic acid dimethyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

Reference yield:

ethyl 4-oxocyclohexane-1-carboxylate (17159-79-4) → 8-ethyl 8-methyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate (340022-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 20 °C

With toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; toluene;

Reference yield: 40.0%

8-ethyl 8-methyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate (340022-79-9) → [8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol (1256546-72-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 50 - 70 ℃; for 1h;

upstream raw materials:

ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

carbonic acid dimethyl ester

ethyl 4-oxocyclohexane-1-carboxylate

Downstream raw materials:

[8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol

(8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)methyl 4-methylbenzenesulfonate

1,4-dioxaspiro[4.5]decane-8,8-diylbis(methylene) dibenzenesulfonate

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