(8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)methyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)methyl 4-methylbenzenesulfonate
CAS No.:1557246-53-3
Molecular Formula:C₁₇H₂₄O₆S
Molecular Weight:356.44
Hs Code.:

Synonyms:(8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)methyl 4-methylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)methyl 4-methylbenzenesulfonate

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Technology Process of (8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)methyl 4-methylbenzenesulfonate

There total 4 articles about (8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)methyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1256546-72-1
[8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol

: 98-59-9
p-toluenesulfonyl chloride

: 1557246-53-3
(8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)methyl 4-methylbenzenesulfonate

Guidance literature:: [8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

p-toluenesulfonyl chloride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1557246-53-3
(8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 50 - 70 °C

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

3.2: 1 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1557246-53-3
(8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 50 - 70 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

4.2: 1 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; toluene;