Potassium N-cyclohexyl-N-methyl-aminomethyltrifluoroborate

Base Information

• Chemical Name: Potassium N-cyclohexyl-N-methyl-aminomethyltrifluoroborate
• CAS No.: 1015484-23-7
• Molecular Formula: C8H16BF3KN
• Molecular Weight: 233.126
• Mol file: 1015484-23-7.mol

Synonyms:Potassium N-cyclohexyl-N-methyl-aminomethyltrifluoroborate

Chemical Property of Potassium N-cyclohexyl-N-methyl-aminomethyltrifluoroborate

Chemical Property:

• Melting Point: 104-107 °C
• PSA: 3.24000
• LogP: 3.05580

Purity/Quality:

98% ^*data from raw suppliers

POTASSIUM N-CYCLOHEXYL-N-METHYLAMINOMETHYLTRIFLUOROBORATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Potassium N-cyclohexyl-N-methyl-aminomethyltrifluoroborate

There total 2 articles about Potassium N-cyclohexyl-N-methyl-aminomethyltrifluoroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

potassium bromomethyl trifluoroborate + N-methylcyclohexylamine (100-60-7) → potassium N-methyl-N-(trifluoroboratomethyl)cyclohexylamine (1015484-23-7)

Guidance literature:

In tetrahydrofuran; at 80 ℃; for 4.5h;

DOI:10.1021/jo800183q

Reference yield: 76.0%

potassium bromomethyl trifluoroborate + benzyl-methyl-amine (103-67-3) → potassium N-methyl-N-(trifluoroboratomethyl)cyclohexylamine (1015484-23-7)

Guidance literature:

potassium bromomethyl trifluoroborate; benzyl-methyl-amine; In tetrahydrofuran; at 20 - 80 ℃; for 2h;

With potassium carbonate; In acetone; for 1h;

DOI:10.1021/acs.joc.0c02958

Reference yield: 85.0%

potassium N-methyl-N-(trifluoroboratomethyl)cyclohexylamine (1015484-23-7) + 4-chloromethoxybenzene (623-12-1) → N-(4-methoxybenzyl)-N-methylcyclohexylamine (92725-40-1)

Guidance literature:

With caesium carbonate; palladium diacetate; XPhos; In tetrahydrofuran; water; at 80 ℃; for 24h;

DOI:10.1021/jo800183q

upstream raw materials:

N-methylcyclohexylamine

benzyl-methyl-amine

Downstream raw materials:

N-(4-methoxybenzyl)-N-methylcyclohexylamine

N-(2-phenethyl)benzylmethylamine

N-methyl-N-(pyridin-3-yl-methyl)cyclohexanamine

Refernces

• 1、 Molander, Gary A.,Gormisky, Paul E.,Sandrock, Deidre L.. "Scope of aminomethylations via Suzuki-Miyaura cross-coupling of orsanotrifluoroborates". . p. 2052 - 2057. Retrieved 2008/09/19.