(2S)-1-BOC-BETA-OXO-2-PIPERIDINEPROPANOIC ACID ETHYL ESTER

Base Information

• Chemical Name: (2S)-1-BOC-BETA-OXO-2-PIPERIDINEPROPANOIC ACID ETHYL ESTER
• CAS No.: 287107-84-0
• Molecular Formula: C₁₅H₂₅NO₅
• Molecular Weight: 299.367
• Mol file: 287107-84-0.mol

Synonyms:(2S)-1-BOC-BETA-OXO-2-PIPERIDINEPROPANOIC ACID ETHYL ESTER

Chemical Property of (2S)-1-BOC-BETA-OXO-2-PIPERIDINEPROPANOIC ACID ETHYL ESTER

Chemical Property:

• Boiling Point: 386.1±32.0 °C(Predicted)
• PKA: 10.30±0.20(Predicted)
• Density: 1.113±0.06 g/cm3(Predicted)

Purity/Quality:

95%-98% ^*data from raw suppliers

(2S)-1-BOC-BETA-OXO-2-PIPERIDINEPROPANOICACIDETHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-1-BOC-BETA-OXO-2-PIPERIDINEPROPANOIC ACID ETHYL ESTER

There total 2 articles about (2S)-1-BOC-BETA-OXO-2-PIPERIDINEPROPANOIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

cycl-isopropylidene malonate (2033-24-1) + ethanol (64-17-5) + (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid (26250-84-0) → tert-butyl (S)-2-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate (287107-84-0)

Guidance literature:

cycl-isopropylidene malonate; (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 48h;

ethanol; for 2h; Reflux;

DOI:10.1002/cmdc.202000268

Reference yield: 61.0%

cycl-isopropylidene malonate (2033-24-1) + ethanol (64-17-5) + N-BOC-D-pipecolic acid (28697-17-8) → tert-butyl (R)-2-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate (287107-84-0)

Guidance literature:

cycl-isopropylidene malonate; N-BOC-D-pipecolic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 48h;

ethanol; for 2h; Reflux;

DOI:10.1002/cmdc.202000268

upstream raw materials:

cycl-isopropylidene malonate

ethanol

(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

N-BOC-D-pipecolic acid

Refernces