2-(Boc-amino)-5-cyanopyridine

Base Information

• Chemical Name: 2-(Boc-amino)-5-cyanopyridine
• CAS No.: 814263-30-4
• Molecular Formula: C₁₁H₁₃N₃O₂
• Molecular Weight: 219.243
• Hs Code.: 2933399090
• Mol file: 814263-30-4.mol

Synonyms:(6-Cyano-pyridin-3-yl)-carbaMic acid tert-butyl ester

Chemical Property of 2-(Boc-amino)-5-cyanopyridine

Chemical Property:

• PSA: 75.01000
• LogP: 2.37328

Purity/Quality:

99%min. ^*data from raw suppliers

5-(Boc-amino)-2-cyanopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Boc-amino)-5-cyanopyridine

There total 1 articles about 2-(Boc-amino)-5-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

di-tert-butyl dicarbonate (24424-99-5) + 5-amino-2-cyanopyridine (55338-73-3) → tert-butyl (6-cyanopyridin-3-yl)carbamate (814263-30-4)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 0 - 60 ℃; for 14h;

Reference yield: 65.0%

tert-butyl (6-cyanopyridin-3-yl)carbamate (814263-30-4) + methylmagnesium bromide (75-16-1) → tert-butyl (6-acetylpyridin-3-yl)carbamate (858599-23-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

tert-butyl (6-cyanopyridin-3-yl)carbamate (814263-30-4) → N-((5-aminopyridin-2-yl)methyl)-5-(4-((2-oxopyridin-1(2H)-yl)methyl)benzyl)nicotinamide

Guidance literature:

Multi-step reaction with 3 steps

1: ammonia; hydrogen / methanol / 20 °C

2: HATU; triethylamine / N,N-dimethyl-formamide / 20 °C

3: hydrogenchloride / methanol / 20 °C

With hydrogenchloride; ammonia; hydrogen; triethylamine; HATU; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

di-tert-butyl dicarbonate

5-amino-2-cyanopyridine

Downstream raw materials:

tert-butyl (6-acetylpyridin-3-yl)carbamate

Refernces

• 1、 -. "THERAPEUTIC INHIBITORY COMPOUNDS". Page/Page column 166. . Retrieved 2015/07/16.