1-(3,3-Dimethylbutan-2-yl)-2-[(diphenylsilyl)oxy]piperazine

Base Information

• Chemical Name: 1-(3,3-Dimethylbutan-2-yl)-2-[(diphenylsilyl)oxy]piperazine
• CAS No.: 887583-71-3
• Molecular Formula: C22H32N2OSi
• Molecular Weight: 368.594
• DSSTox Substance ID: DTXSID50723075
• Mol file: 887583-71-3.mol

Synonyms:DTXSID50723075;1-(3,3-Dimethylbutan-2-yl)-2-[(diphenylsilyl)oxy]piperazine

Chemical Property of 1-(3,3-Dimethylbutan-2-yl)-2-[(diphenylsilyl)oxy]piperazine

Chemical Property:

• PSA: 24.50000
• LogP: 2.73490
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 367.220565151
• Heavy Atom Count: 26
• Complexity: 395

Purity/Quality:

1-[2-[(tert-Butyldiphenylsilyl)oxy]ethyl]piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C)(C)C)N1CCNCC1O[Si](C2=CC=CC=C2)C3=CC=CC=C3
• Uses: 1-[2-[(tert-Butyldiphenylsilyl)oxy]ethyl]piperazine is used in the preparation of inhibitors that promote apoptosis for treatment of cancer.

Technology Process of 1-(3,3-Dimethylbutan-2-yl)-2-[(diphenylsilyl)oxy]piperazine

There total 1 articles about 1-(3,3-Dimethylbutan-2-yl)-2-[(diphenylsilyl)oxy]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(2-hydroxyethyl)piperazine (103-76-4) + tert-butylchlorodiphenylsilane (58479-61-1) → 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]piperazine (887583-71-3)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 18 - 25 ℃;

Reference yield: 100.0%

1-[2-(tert-butyldiphenylsilanyloxy)ethyl]piperazine (887583-71-3) + (R)-4-(phenylthio)-3-((4-sulfamoyl-2-((trifluoromethyl)sulfonyl)phenyl)amino)butanoic acid (1357575-05-3) → (R)-4-((4-(4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)piperazin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide (1357575-16-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In ISOPROPYLAMIDE; at 18 - 25 ℃; for 2h;

Reference yield: 90.0%

methyl 2-(6-chloro-2-methylpyrimidin-4-yl-amino)thiazol-5-carboxylate + 1-[2-(tert-butyldiphenylsilanyloxy)ethyl]piperazine (887583-71-3) → C32H40N6O3SSi

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 100 - 105 ℃;

upstream raw materials:

1-(2-hydroxyethyl)piperazine

tert-butylchlorodiphenylsilane

Downstream raw materials:

(R)-4-((4-(4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)piperazin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

N-(4-((R)-4-(4-(2-(tert-butyldiphenylsilyloxy)ethyl)piperazin-1-yl)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)-4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzamide

4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)-N-(4-((R)-4-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide

(R)-4-((4-(4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)piperazin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

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