6-METHYL-2,3-DIHYDRO-PYRIDO[3,2-B][1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 6-METHYL-2,3-DIHYDRO-PYRIDO[3,2-B][1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 381226-84-2
• Molecular Formula: C₁₃H₁₈N₂O₃
• Molecular Weight: 250.298
• Hs Code.: 2934999090
• Mol file: 381226-84-2.mol

Synonyms:6-METHYL-2,3-DIHYDRO-PYRIDO[3,2-B][1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-Butyl 6-methyl-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

Chemical Property of 6-METHYL-2,3-DIHYDRO-PYRIDO[3,2-B][1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• PSA: 51.66000
• LogP: 2.58890

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl6-methyl-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHYL-2,3-DIHYDRO-PYRIDO[3,2-B][1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 5 articles about 6-METHYL-2,3-DIHYDRO-PYRIDO[3,2-B][1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

di-tert-butyl dicarbonate (24424-99-5) + 6-methyl-3,4-dihydro-2h-pyrido[3,2-b][1,4]oxazine (20567-67-3) → 2,3-dihydro-6-methyl-4H-pyrido[3,2-b]-1,4-oxazine-4-carboxylic acid, 1,1-dimethylethyl ester (381226-84-2)

Guidance literature:

at 60 ℃;

DOI:10.1016/j.bmcl.2005.01.028

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2,3-dihydro-6-methyl-4H-pyrido[3,2-b]-1,4-oxazine-4-carboxylic acid, 1,1-dimethylethyl ester (381226-84-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

Reference yield:

6-methyl-2-nitropyridin-3-ol (15128-90-2) → 2,3-dihydro-6-methyl-4H-pyrido[3,2-b]-1,4-oxazine-4-carboxylic acid, 1,1-dimethylethyl ester (381226-84-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / H₂ / Pd/C / ethyl acetate

2: 79 percent / aq. NaHCO₃ / butan-2-one

3: 99 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / 20 °C

4: 80 percent / 60 °C

With lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; butanone;

DOI:10.1016/j.bmcl.2005.01.028

upstream raw materials:

di-tert-butyl dicarbonate

6-methyl-3,4-dihydro-2h-pyrido[3,2-b][1,4]oxazine

2-amino-3-hydroxy-6-methylpyridine

6-methyl-2-nitropyridin-3-ol

Downstream raw materials:

6-[2-(3-methyl-4-nitro-phenoxy)-ethyl]-2,3-dihydro-pyrido[3,2-b][1,4]oxazine-4-carboxylic acid tert-butyl ester

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