15128-90-2

Basic information

• Product Name: 3-HYDROXY-6-METHYL-2-NITROPYRIDINE
• Synonyms: 3-Pyridinol, 6-methyl-2-nitro-;3-HYDROXY-6-METHYL-2-NITROPYRIDINE;6-METHYL-2-NITRO-3-HYDROXYPYRIDINE;6-METHYL-2-NITRO-3-PYRIDINOL;5-HYDROXY-2-METHYL-6-NITROPYRIDINE;6-methyl-2-nitropyridin-3-ol;5-hydroxy-6-nitro-2-picoline;3-HYDROXY-6-METHYL-2-NITROPYRIDINE 99%
• CAS NO: 15128-90-2
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.12
• EINECS: 239-192-8
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Pyridine
• Mol File: 15128-90-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 106-107 °C(lit.)
• Boiling Point: 277.46°C (rough estimate)
• Flash Point: 177.8 °C
• Appearance: yellow fine crystalline powder
• Density: 1.4564 (rough estimate)
• Vapor Pressure: 5.2E-06mmHg at 25°C
• Refractive Index: 1.5100 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.01±0.22(Predicted)
• BRN: 974751
• CAS DataBase Reference: 3-HYDROXY-6-METHYL-2-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXY-6-METHYL-2-NITROPYRIDINE(15128-90-2)
• EPA Substance Registry System: 3-HYDROXY-6-METHYL-2-NITROPYRIDINE(15128-90-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• Hazardous Substances Data: 15128-90-2(Hazardous Substances Data)

Usage

Chemical Properties

yellow fine crystalline powder

Uses

Different sources of media describe the Uses of 15128-90-2 differently. You can refer to the following data:
1. 3-Hydroxy-6-methyl-2-nitropyridine was used in the synthesis of 3-methoxy-6-methyl-2-nitropyridine.Molecular structure and corresponding vibrational assignments of 3-hydroxy-6-methyl-2-nitropyridine have been investigated using density functional theory (DFT).
2. 3-Hydroxy-6-methyl-2-nitropyridine was used in the synthesis of 3-methoxy-6-methyl-2-nitropyridine.

General Description

Molecular structure and corresponding vibrational assignments of 3-hydroxy-6-methyl-2-nitropyridine have been investigated using density functional theory (DFT).

InChI:InChI=1/C6H6N2O3/c1-4-2-3-5(9)6(7-4)8(10)11/h2-3,9H,1H3

Upstream product

• 42097-42-7 3-hydroxy-2-hydroxymethyl-6-methylpyridine 
• 1121-78-4 5-Hydroxy-2-methylpyridine 

Downstream Products

• 24015-98-3 3-methoxy-6-methyl-2-nitro-pyridine 
• 209328-87-0 2-fluoro-6-methylpyridin-3-ol 
• 55656-32-1 5-Methyl-3H-oxazolo<4,5-b>pyridine-2-thione 
• 1574636-24-0 (E)-2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetic acid 
• 1574636-22-8 (E)-ethyl 2-((3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)amino)acetate 
• 1574636-15-9 (E)-N-(3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-yl)acetamide 
• 55656-32-1 5-methyloxazolo[4,5-b]pyridine-2-thiol 
• 478913-57-4 2-amino-3-methoxy-6-methylpyridine 
• 1353547-89-3 (E)-N-(3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridine-2-yl)methanesulfonamide 
• 1353547-85-9 (E)-3-methoxy-2-(piperidin-1-yl)-6-((2,4,6-trimethoxystyrylsulfonyl)methyl)pyridine 
• 1353547-84-8 (E)-3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-amine 
• 1353547-83-7 (E)-3-methoxy-2-nitro-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridine 
• 1355026-14-0 C₁₄H₁₂BrClN₂O₄ 
• 1355026-13-9 C₁₄H₁₂BrClN₂O₄ 

Relevant articles and documents

Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Br?nsted Acidic NO2+ Generation

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Br?nsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.

3-Pyridyl enantiomers and their use as analgesics

The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: STR1 or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

Medicinal oxazolopyridine compounds

Compounds of general formula (I): STR1 in which: R1 and R2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link, W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3, A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms, R3 and R4 are defined in the description have medicinal properties.