2,3-Diamino-6-iodopyridine

Base Information

• Chemical Name: 2,3-Diamino-6-iodopyridine
• CAS No.: 351447-14-8
• Molecular Formula: C₅H₆IN₃
• Molecular Weight: 235.027
• Mol file: 351447-14-8.mol

Synonyms:2,3-Diamino-6-iodopyridine

Chemical Property of 2,3-Diamino-6-iodopyridine

Chemical Property:

• Boiling Point: 395.6±42.0 °C(Predicted)
• PKA: 3.25±0.50(Predicted)
• PSA: 64.93000
• Density: 2.150±0.06 g/cm3(Predicted)
• LogP: 2.01300

Purity/Quality:

97% ^*data from raw suppliers

6-Iodo-pyridine-2,3-diamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Diamino-6-iodopyridine

There total 3 articles about 2,3-Diamino-6-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

6-iodo-3-nitropyridin-2-amine (351447-13-7) → 6-iodopyridine-2,3-diamine (351447-14-8)

Guidance literature:

With hydrogenchloride; stannous chloride hydrate; In water; at 25 - 65 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.201601505

Reference yield:

6-iodo-3-nitropyridin-2-amine (351447-13-7) + iron (7439-89-6) → 6-iodopyridine-2,3-diamine (351447-14-8)

Guidance literature:

With ammonium chloride; In EtOH-H₂O;

Reference yield:

2-amino-6-chloro-3-nitropyridine (27048-04-0) → 6-iodopyridine-2,3-diamine (351447-14-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen iodide / water / 72 h / 25 °C / Inert atmosphere

2: stannous chloride hydrate; hydrogenchloride / water / 3 h / 25 - 65 °C / Inert atmosphere

With hydrogenchloride; stannous chloride hydrate; hydrogen iodide; In water;

DOI:10.1002/chem.201601505

upstream raw materials:

6-iodo-3-nitropyridin-2-amine

iron

2-amino-6-chloro-3-nitropyridine

Refernces

• 1、 -. "Alpha V integrin receptor antagonists". . . Retrieved 2008/06/13.