4-FORMYL-INDAN-1-ONE 1,2-ETHANEDIOL KETAL

Base Information

• Chemical Name: 4-FORMYL-INDAN-1-ONE 1,2-ETHANEDIOL KETAL
• CAS No.: 954238-31-4
• Molecular Formula: C₁₂H₁₂O₃
• Molecular Weight: 204.225
• Mol file: 954238-31-4.mol

Synonyms:4-FORMYL-INDAN-1-ONE 1,2-ETHANEDIOL KETAL

Chemical Property of 4-FORMYL-INDAN-1-ONE 1,2-ETHANEDIOL KETAL

Chemical Property:

• Boiling Point: 355.9±42.0 °C (760 mmHg)
• PSA: 35.53000
• Density: 1.27±0.1 g/cm3 (20 °C, 760 mmHg)
• LogP: 1.64490

Purity/Quality:

99% ^*data from raw suppliers

4-Formyl-indan-1-one1,2-ethanediolketal 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FORMYL-INDAN-1-ONE 1,2-ETHANEDIOL KETAL

There total 2 articles about 4-FORMYL-INDAN-1-ONE 1,2-ETHANEDIOL KETAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromoindan-1-one-1,2-ethylene ketal (908334-04-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-formylindan-1-one-1,2-ethylene ketal (954238-31-4)

Guidance literature:

4-bromoindan-1-one-1,2-ethylene ketal; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.bmcl.2006.05.052

Reference yield:

4-bromo-2,3-dihydroinden-1-one (15115-60-3) → 4-formylindan-1-one-1,2-ethylene ketal (954238-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: p-TsOH / benzene / Heating

2.1: nBuLi / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran / -78 - 20 °C

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

DOI:10.1016/j.bmcl.2006.05.052

Reference yield:

4-formylindan-1-one-1,2-ethylene ketal (954238-31-4) → 2-benzoyl-4-(4-methyl-piperazin-1-ylmethyl)-indan-1-one

Guidance literature:

Multi-step reaction with 5 steps

1: NaBH₄ / ethanol; tetrahydrofuran / 0 - 20 °C

2: aq. p-TsOH / acetone / Heating

3: Et₃N / tetrahydrofuran / 0 °C

4: K₂CO₃ / ethanol / 0 - 20 °C

5: NaH / benzene / Heating

With sodium tetrahydroborate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; ethanol; acetone; benzene;

DOI:10.1016/j.bmcl.2006.05.052

upstream raw materials:

4-bromoindan-1-one-1,2-ethylene ketal

N,N-dimethyl-formamide

4-bromo-2,3-dihydroinden-1-one

Refernces