4-Bromo-1,1-(ethylenedioxo)-indane

Base Information

• Chemical Name: 4-Bromo-1,1-(ethylenedioxo)-indane
• CAS No.: 908334-04-3
• Molecular Formula: C₁₁H₁₁BrO₂
• Molecular Weight: 255.111
• Hs Code.: 2932999099
• Mol file: 908334-04-3.mol

Synonyms:4-Bromo-indan-1-one 1,2-ethanediol ketal

Chemical Property of 4-Bromo-1,1-(ethylenedioxo)-indane

Chemical Property:

• PSA: 18.46000
• LogP: 2.59490

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-indan-1-one1,2-ethanediolketal 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Bromo-1,1-(ethylenedioxo)-indane

There total 1 articles about 4-Bromo-1,1-(ethylenedioxo)-indane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

4-bromo-2,3-dihydroinden-1-one (15115-60-3) + ethylene glycol (107-21-1) → 4-bromoindan-1-one-1,2-ethylene ketal (908334-04-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 90 ℃; for 15h; Temperature;

Reference yield:

4-bromoindan-1-one-1,2-ethylene ketal (908334-04-3) → 2-benzoyl-4-(4-methyl-piperazin-1-ylmethyl)-indan-1-one

Guidance literature:

Multi-step reaction with 6 steps

1.1: nBuLi / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: NaBH₄ / ethanol; tetrahydrofuran / 0 - 20 °C

3.1: aq. p-TsOH / acetone / Heating

4.1: Et₃N / tetrahydrofuran / 0 °C

5.1: K₂CO₃ / ethanol / 0 - 20 °C

6.1: NaH / benzene / Heating

With sodium tetrahydroborate; n-butyllithium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; ethanol; acetone; benzene;

DOI:10.1016/j.bmcl.2006.05.052

Reference yield:

4-bromoindan-1-one-1,2-ethylene ketal (908334-04-3) → 5-(4-methyl-piperazin-1-ylmethyl)-3-phenyl-1,4-dihydro-indeno[1,2-c]pyrazole

Guidance literature:

Multi-step reaction with 7 steps

1.1: nBuLi / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: NaBH₄ / ethanol; tetrahydrofuran / 0 - 20 °C

3.1: aq. p-TsOH / acetone / Heating

4.1: Et₃N / tetrahydrofuran / 0 °C

5.1: K₂CO₃ / ethanol / 0 - 20 °C

6.1: NaH / benzene / Heating

7.1: hydrazine hydrate; AcOH / ethanol / Heating

With sodium tetrahydroborate; n-butyllithium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; acetone; benzene;

DOI:10.1016/j.bmcl.2006.05.052

upstream raw materials:

4-bromo-2,3-dihydroinden-1-one

ethylene glycol

Downstream raw materials:

4-formylindan-1-one-1,2-ethylene ketal