tert-butyl-3-(N'-hydroxycarbamimidoyl)morpholine-4-carboxylate

Base Information

• Chemical Name: tert-butyl-3-(N'-hydroxycarbamimidoyl)morpholine-4-carboxylate
• CAS No.: 518058-62-3
• Molecular Formula: C₁₀H₁₉N₃O₄
• Molecular Weight: 245.279
• Mol file: 518058-62-3.mol

Synonyms:tert-butyl-3-(N'-hydroxycarbamimidoyl)morpholine-4-carboxylate

Chemical Property of tert-butyl-3-(N'-hydroxycarbamimidoyl)morpholine-4-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-[(HYDROXYAMINO)IMINOMETHYL]-4-MORPHOLINECARBOXYLIC ACID-1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-3-(N'-hydroxycarbamimidoyl)morpholine-4-carboxylate

There total 6 articles about tert-butyl-3-(N'-hydroxycarbamimidoyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tert-butyl 3-cyanomorpholine-4-carboxylate (518047-40-0,1257856-86-2) → tert-butyl 3-[amino(hydroxyimino)methyl]morpholine-4-carboxylate (518058-62-3,519031-82-4)

Guidance literature:

With hydroxylamine;

DOI:10.1016/j.tet.2016.12.052

Reference yield:

tert-butyl 3-cyanomorpholine-4-carboxylate (518047-40-0,1257856-86-2) → tert-butyl 3-[amino(hydroxyimino)methyl]morpholine-4-carboxylate (518058-62-3,519031-82-4)

Guidance literature:

With hydroxylamine; In methanol; at 60 ℃;

DOI:10.1021/jm070027u

Reference yield:

tert-butyl 3-(aminocarbonyl)morpholine 4-carboxylate (518047-39-7,1476028-20-2,1476028-21-3) → tert-butyl 3-[amino(hydroxyimino)methyl]morpholine-4-carboxylate (518058-62-3,519031-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Et₃N; trifluoroacetic anhydride / CH₂Cl₂ / 3.5 h / 20 °C

2: NH₂OH / methanol / 60 °C

With hydroxylamine; triethylamine; trifluoroacetic anhydride; In methanol; dichloromethane;

DOI:10.1021/jm070027u

upstream raw materials:

tert-butyl 3-cyanomorpholine-4-carboxylate

tert-butyl 3-(aminocarbonyl)morpholine 4-carboxylate

4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid

morpholine-4-carboxylic acid tert-butyl ester

Downstream raw materials:

tert-butyl 3-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]morpholine-4-carboxylate

N-(4-fluorobenzyl)-5,6-dihydroxy-2-(morpholin-3-yl)pyrimidine-4-carboxamide