3-[(benzyloxy)methyl]-3-fluorooxetane

Base Information

• Chemical Name: 3-[(benzyloxy)methyl]-3-fluorooxetane
• CAS No.: 865451-84-9
• Molecular Formula: C11H13FO2
• Molecular Weight: 196.221
• Hs Code.: 2932999099
• Mol file: 865451-84-9.mol

Synonyms:3-[(benzyloxy)methyl]-3-fluorooxetane

Chemical Property of 3-[(benzyloxy)methyl]-3-fluorooxetane

Chemical Property:

• PSA: 18.46000
• LogP: 1.94170
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-[(Benzyloxy)methyl]-3-fluoro-oxetane 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(benzyloxy)methyl]-3-fluorooxetane

There total 3 articles about 3-[(benzyloxy)methyl]-3-fluorooxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

3-(benzyloxy)-2-(bromomethyl)-2-fluoropropan-1-ol (865451-83-8) → 3-benzyloxymethyl-3-fluorooxetane (865451-84-9)

Guidance literature:

With potassium carbonate; In acetonitrile; for 72h; Heating / reflux;

Reference yield:

benzyl bromide (100-39-0) → 3-benzyloxymethyl-3-fluorooxetane (865451-84-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: triethylamine hydrofluoride; N-Bromosuccinimide / dichloromethane / 3 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

With N-Bromosuccinimide; sodium hydride; triethylamine hydrofluoride; In tetrahydrofuran; dichloromethane;

Reference yield:

2?(benzyloxymethyl)prop?2?en?1?ol (109240-66-6) → 3-benzyloxymethyl-3-fluorooxetane (865451-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine hydrofluoride; N-Bromosuccinimide / dichloromethane / 3 h / 0 - 20 °C

2: sodium hydride / tetrahydrofuran / 0 - 20 °C

With N-Bromosuccinimide; sodium hydride; triethylamine hydrofluoride; In tetrahydrofuran; dichloromethane;

upstream raw materials:

3-(benzyloxy)-2-(bromomethyl)-2-fluoropropan-1-ol

benzyl bromide

2?(benzyloxymethyl)prop?2?en?1?ol

Downstream raw materials:

(3-fluorooxetan- 3-yl) methanol

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