Rivaroxaban Impurity H

Base Information

Chemical Name:Rivaroxaban Impurity H
CAS No.:1807455-76-0
Molecular Formula:
Molecular Weight:611.52
Hs Code.:

Synonyms:Rivaroxaban Impurity H;(S)-5-chloro-N-(4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-N-(2-(2-(methylamino)-2-oxoethoxy)ethyl)thiophene-2-carboxamide

Suppliers and Price of Rivaroxaban Impurity H

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4''-Desmorpholino4''-[N-(5-chloro-2-carboxy-thienyl)N-(5-Carboxy-3-oxa-pentyl)]aminoRivaroxaban
5mg
$ 455.00

TRC
4''-Desmorpholino4''-[N-(5-chloro-2-carboxy-thienyl)N-(5-Carboxy-3-oxa-pentyl)]aminoRivaroxaban
2.5mg
$ 205.00

Total 11 raw suppliers

Chemical Property of Rivaroxaban Impurity H

Chemical Property:

Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4''-Desmorpholino4''-[N-(5-chloro-2-carboxy-thienyl)N-(5-Carboxy-3-oxa-pentyl)]aminoRivaroxaban ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4''-Desmorpholino 4''-[N-(5-chloro-2-carboxy-thienyl) N-(5-Carboxy-3-oxa-pentyl)]amino Rivaroxaban is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.

Technology Process of Rivaroxaban Impurity H

There total 18 articles about Rivaroxaban Impurity H which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.3%

: 2-{2-[1-(5-chlorothiophen-2-yl)-N-{4-[(5S)-5-{[(5-chlorothiophen-2-yl)formamido]methyl}-2-oxo-1,3-oxazolidin-3-yl]phenyl}formamido]ethoxy}acetyl chloride

: 74-89-5
methylamine

: 1807455-76-0
C₂₅H₂₄Cl₂N₄O₆S₂

Guidance literature:: In dichloromethane; at -5 - 20 ℃; for 6h;

Reference yield: 50.2%

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: C₁₅H₂₂N₄O₄*2ClH

: 1807455-76-0
C₂₅H₂₄Cl₂N₄O₆S₂

Guidance literature:: 5-Chlorothiophene-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 10 - 20 ℃; Cooling with ice;

With triethylamine; In N,N-dimethyl-formamide; at 10 - 20 ℃;

C₁₅H₂₂N₄O₄*2ClH; In N,N-dimethyl-formamide; at 30 - 35 ℃;