3-(difluoromethyl)azetidine hydrochloride

Base Information

• Chemical Name: 3-(difluoromethyl)azetidine hydrochloride
• CAS No.: 1354792-76-9
• Molecular Formula: C4H8ClF2N
• Molecular Weight: 143.564
• Hs Code.: 2933998090
• Mol file: 1354792-76-9.mol

Synonyms:3-(difluoromethyl)azetidine hydrochloride

Chemical Property of 3-(difluoromethyl)azetidine hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 1.60170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3-(Difluoromethyl)azetidinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(difluoromethyl)azetidine hydrochloride

There total 1 articles about 3-(difluoromethyl)azetidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 3-(difluoromethyl)azetidine-1-carboxylate (1354792-75-8) → 3-(difluoromethyl)azetidine hydrochloride (1354792-76-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 24h;

Reference yield: 94.0%

3-(difluoromethyl)azetidine hydrochloride (1354792-76-9) + rac-(5aR,6S,7R,8R,8aS)-5a-(4-bromophenyl)-3-chloro-8,8a-dihydroxy-1-methoxy-6-phenyl-5a,7,8,8a-tetrahydro-6H-cyclopenta[4,5]furo[3,2-c]pyridine-7-carboxylic acid → rac-((5aR,6S,7R,8R,8aS)-5a-(4-bromophenyl)-3-chloro-8,8a-dihydroxy-1-methoxy-6-phenyl-5a,7,8,8a-tetrahydro-6H-cyclopenta[4,5]furo[3,2-c]pyridin-7-yl)(3-(difluoromethyl)azetidin-1-yl)methanone

Guidance literature:

With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 1.08333h; Alkaline conditions;

Reference yield: 76.0%

3-(difluoromethyl)azetidine hydrochloride (1354792-76-9) + ((5-(4-(2-bromoethoxy)phenyl)-6-phenyl-7,8-dihydronaphthalen-2-yl)oxy)triisopropylsilane → cis-3-(difluoromethyl)-1-(2-(4-(2-phenyl-6-((triisopropylsilyl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy)ethyl)azetidine

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃; for 16h;

upstream raw materials:

tert-butyl 3-(difluoromethyl)azetidine-1-carboxylate

Downstream raw materials:

(3-(4-((3-(difluoromethyl)azetidin-1-yl)methyl)phenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1354792-76-9 3-(difluoromethyl)azetidine hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send