(3-(4-((3-(difluoromethyl)azetidin-1-yl)methyl)phenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

Base Information

Chemical Name:(3-(4-((3-(difluoromethyl)azetidin-1-yl)methyl)phenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone
CAS No.:1354791-88-0
Molecular Formula:C₂₃H₂₂F₂N₄O₃
Molecular Weight:440.449
Hs Code.:

Synonyms:(3-(4-((3-(difluoromethyl)azetidin-1-yl)methyl)phenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

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Chemical Property of (3-(4-((3-(difluoromethyl)azetidin-1-yl)methyl)phenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

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Technology Process of (3-(4-((3-(difluoromethyl)azetidin-1-yl)methyl)phenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

There total 4 articles about (3-(4-((3-(difluoromethyl)azetidin-1-yl)methyl)phenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1354792-76-9
3-(difluoromethyl)azetidine hydrochloride

: 1354792-74-7
4-(1-(5-phenyl-1,3,4-oxadiazole-2-carbonyl)azetidin-3-yloxy)benzaldehyde

: 1354791-88-0
(3-(4-((3-(difluoromethyl)azetidin-1-yl)methyl)phenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 16691-25-1
ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate

: 1354791-88-0
(3-(4-((3-(difluoromethyl)azetidin-1-yl)methyl)phenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; sodium cyanide / methanol / 0.33 h / 20 °C

2: triethylamine / dichloromethane / Cooling with ice

3: caesium carbonate / N,N-dimethyl acetamide / 5 h / 110 °C

4: N-ethyl-N,N-diisopropylamine; sodium tris(acetoxy)borohydride / dichloromethane / 5 h / 20 °C

With sodium cyanide; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 1254035-92-1
(3-hydroxyazetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

: 1354791-88-0
(3-(4-((3-(difluoromethyl)azetidin-1-yl)methyl)phenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / Cooling with ice

2: caesium carbonate / N,N-dimethyl acetamide / 5 h / 110 °C

3: N-ethyl-N,N-diisopropylamine; sodium tris(acetoxy)borohydride / dichloromethane / 5 h / 20 °C

With sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl acetamide;