1-Boc-4-methylpiperidine-4-carboxamide

Base Information

• Chemical Name: 1-Boc-4-methylpiperidine-4-carboxamide
• CAS No.: 343788-67-0
• Molecular Formula: C12H22N2O3
• Molecular Weight: 242.318
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20693933
• Wikidata: Q82622922
• Mol file: 343788-67-0.mol

Synonyms:1-BOC-4-METHYLPIPERIDINE-4-CARBOXAMIDE;343788-67-0;tert-Butyl 4-carbamoyl-4-methylpiperidine-1-carboxylate;4-Carbamoyl-4-methyl-piperidine-1-carboxylic acid tert-butyl ester;1-BOC-4-CARBAMOYL-4-METHYLPIPERIDINE;MFCD11223485;SCHEMBL346481;DTXSID20693933;SOVXDRHZKKDYSX-UHFFFAOYSA-N;tert-butyl 4-(aminocarbonyl)-4-methylpiperidine-1-carboxylate;AKOS015902465;AM10332;SB36730;AS-35609;SY003733;METHYL6-NITROPYRIDINE-2-CARBOXYLATE;CS-0171861;FT-0747278;A875002;1-tert-butoxycarbonyl-4-methylpiperidine-4-carboxamide

Chemical Property of 1-Boc-4-methylpiperidine-4-carboxamide

Chemical Property:

• Vapor Pressure: 4.35E-06mmHg at 25°C
• Boiling Point: 383.6°C at 760 mmHg
• PKA: 16.40±0.20(Predicted)
• Flash Point: 185.8°C
• PSA: 72.63000
• Density: 1.093g/cm³
• LogP: 2.14710
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 242.16304257
• Heavy Atom Count: 17
• Complexity: 312

Purity/Quality:

97% ^*data from raw suppliers

1-BOC-4-Methylpiperidine-4-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCN(CC1)C(=O)OC(C)(C)C)C(=O)N

Technology Process of 1-Boc-4-methylpiperidine-4-carboxamide

There total 5 articles about 1-Boc-4-methylpiperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-cyano-4-methylpiperidine-1-carboxylic acid tert-butyl ester (530115-96-9) → 4-carbamoyl-4-methylpiperidine-1-carboxylic acid tert-butyl ester (343788-67-0)

Guidance literature:

With dihydrogen peroxide; potassium carbonate; In dimethyl sulfoxide; at 60 ℃;

Reference yield: 92.0%

→ 4-carbamoyl-4-methylpiperidine-1-carboxylic acid tert-butyl ester (343788-67-0)

Guidance literature:

Reference yield: 78.0%

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid (189321-63-9) → 4-carbamoyl-4-methylpiperidine-1-carboxylic acid tert-butyl ester (343788-67-0)

Guidance literature:

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.333333h;

With ammonium chloride; In N,N-dimethyl-formamide;

upstream raw materials:

ethyl tert-butyl 4-methylpiperidine-1,4-dicarboxylate

4-cyano-4-methylpiperidine-1-carboxylic acid tert-butyl ester

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid

1-tert-butoxycarbonyl-4-cyanopiperidine

Downstream raw materials:

4-methylpiperidine-4-carboxamide 4-methylbenzenesulfonate

4-methyl-4-thiocarbamoylpiperidine-1-carboxylic acid tert-butyl ester

4-[4-(4-methanesulfonylphenoxymethyl)thiazol-2-yl]-4-methylpiperidine-1-carboxylic acid tert-butyl ester