Technology Process of 2-Fluoro-4-hydroxy-3-methoxypyridine
There total 3 articles about 2-Fluoro-4-hydroxy-3-methoxypyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-fluoro-3-methoxypyridine;
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
With
Trimethyl borate;
In
tetrahydrofuran; hexane;
for 2h;
With
peracetic acid;
In
tetrahydrofuran; hexane; water; acetic acid;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 °C / Inert atmosphere
1.3: 1 h / -78 - 0 °C / Inert atmosphere
2.1: potassium carbonate / acetone / Reflux
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
3.2: 2 h / -78 °C / Inert atmosphere
3.3: 1 h / -78 - 0 °C / Inert atmosphere
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium carbonate; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; acetone;
DOI:10.1021/jm201475u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / Reflux
2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 °C / Inert atmosphere
2.3: 1 h / -78 - 0 °C / Inert atmosphere
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium carbonate;
In
tetrahydrofuran; hexane; acetone;
DOI:10.1021/jm201475u