174669-74-0

Basic information

• Product Name: 2-Fluoro-3-hydroxypyridine
• Synonyms: 2-FLUORO-3-HYDROXYPYRIDINE;2-FLUOROPYRIDINE-3-OL;3-FLUORO-2-HYDROXYPYRIDINE;2-Fluoro-3-hydroxypyridine97%;3-Pyridinol,2-fluoro-(9CI);2-Fluoro-3-pyridinol;2-Fluoropyridin-3-ol;3-fluoro-2-hdyroxypyridine
• CAS NO: 174669-74-0
• Molecular Formula: C₅H₄FNO
• Molecular Weight: 113.09
• EINECS: 1312995-182-4
• Product Categories: HALIDE;PYRIDINE;Pyridines;Boronic Acid;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Fluorine series
• Mol File: 174669-74-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 131-133°C
• Boiling Point: 306.7 °C at 760 mmHg
• Flash Point: 139.3 °C
• Appearance: light yellow cryst
• Density: 1.325 g/cm³
• Vapor Pressure: 0.000418mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Room temperature.
• Solubility: DMSO, Methanol
• PKA: 4.92±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoro-3-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-3-hydroxypyridine(174669-74-0)
• EPA Substance Registry System: 2-Fluoro-3-hydroxypyridine(174669-74-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 174669-74-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

Uses

Different sources of media describe the Uses of 174669-74-0 differently. You can refer to the following data:
1. As a pyridine derivative, 2-Fluoro-3-hydroxypyridine can be used in the preparation of imaging agents for nicotinic α4β2 receptor.
2. A pyridine derivative used in the preparation of imaging agents for nicotinic α4β2 receptor.

InChI:InChI=1/C5H4FNO/c6-5-4(8)2-1-3-7-5/h1-3,8H

Upstream product

• 372-48-5 2-fluoropyridine 
• 16867-03-1 2-amino-3-hydroxypyridine 
• 7722-84-1 dihydrogen peroxide 
• 174669-73-9 (2-fluoro-pyridin-3-yl)boronic acid 
• 113975-22-7 2-fluoro-3-iodopyridine 
• 205594-62-3 2-iodo-3-cyclopropylmethoxypyridine 
• 40263-57-8 2-iodo-3-hydroxypyridine 
• 205594-63-4 2-fluoro-3-cyclopropylmethoxypyridine 

Downstream Products

• 186593-24-8 2-Fluoro-3-(1-Cbz-2-(S)-azetidinylmethoxy)pyridine 
• 1310821-60-3 {(3S,4R)-4-(3,4-Dichloro-phenyl)-1-[1-(1-methyl-cyclopropanecarbonyl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-methyl-carbamic acid 2-fluoro-pyridin-3-yl ester 
• 1318801-00-1 C₂₁H₂₁ClFN₃O 
• 1027026-71-6 C₂₁H₂₂ClN₃O₂ 
• 1216143-65-5 C₁₂H₁₁Cl₂N₃O 
• 1318800-54-2 C₁₁H₉Cl₂N₃O 
• 1318800-55-3 C₁₂H₁₂ClN₃O 
• 1339958-98-3 C₁₁H₆Cl₂FNO 
• 1215868-70-4 5-bromo-2-(2-fluoropyridin-3-yloxy)benzoic acid 
• 1357366-93-8 2-(5-amino-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)phenol 
• 1215868-71-5 5-bromo-N,N-diethyl-2-(2-fluoropyridin-3-yloxy)benzamide 
• 1215868-72-6 3-(4-bromo-2-(diethylcarbamoyl)phenoxy)-2-fluoropyridine 1-oxide 
• 1215868-73-7 5-bromo-2-(6-chloro-2-fluoropyridin-3-yloxy)-N,N-diethylbenzamide 
• 1184172-38-0 2-fluoro-3-methoxypyridin-4-ol 

Relevant articles and documents

[18F]FPyKYNE, a fluoropyridine-based alkyne reagent designed for the fluorine-18 labelling of macromolecules using click chemistry

FPyKYNE (2-fluoro-3-pent-4-yn-1-yloxypyridine) is a novel fluoropyridine-based structure, designed for the fluorine-18 labelling of macromolecules using copper-catalysed Huisgen 1,3-dipolar cycloaddition (click chemistry). FPyKYNE (non-labelled as reference), as well as the 2-bromo, 2-nitro and 2-trimethylammonium analogues (as precursors for labelling with fluorine-18), was synthesized in 44, 95, 60 and 41%, respectively, from commercially available 5-chloropent-1-yne and the appropriate 2-substituted-3-hydroxypyridines. [18F]FPyKYNE was synthesized in one single radiochemical step by reaction of no-carrier-added K[ 18F]F-Kryptofix 222 (DMSO, 165°C, 3-5 min) followed by C-18 SepPak cartridge pre-purification and finally semi-preparative HPLC purification on a Hewlett Packard SiO2 Zorbax Rx-SIL. Using the 2-nitropyridine or the pyridin-2-yltrimethylammonium trifluoromethanesulphonate precursor for labelling (30 and 10 μmol, respectively), incorporation yields up to 90% were observed and 7.0-8.9 GBq (190-240 mCi) of [18F]FPyKYNE ([18F]-1) could be isolated within 60-70 min (HPLC purification included), starting from a 37.0 GBq (1.0 Ci) [18F]fluoride batch (overall decay-corrected and isolated yields: 30-35%). Copyright

Cu(I)/sucrose-catalyzed hydroxylation of arenes in water: The dual role of sucrose

A protocol for the hydroxylation of aryl halides catalyzed by copper(I) and sucrose in neat water has been developed. The dual role of sucrose, the reaction pathway, and the high selectivity for hydroxylation were investigated using a combination of experimental and theoretical techniques. This journal is

Novel synthetic approach to fluoro- and amido-disubstituted 3-hydroxypyridin-4-ones

Starting from fluoropyridines as a building block, with chelating functional groups being introduced, several fluoro- and amido-disubstituted 3-hydroxypyridin-4-ones have been synthesized with the intention of improving the pharmaceutical profile of 3-hydroxypyridin-4-ones.

BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS

The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.