2-Fluoro-3-hydroxypyridine

Base Information

Chemical Name:2-Fluoro-3-hydroxypyridine
CAS No.:174669-74-0
Molecular Formula:C5H4FNO
Molecular Weight:113.091
Hs Code.:29339900
European Community (EC) Number:640-435-9
DSSTox Substance ID:DTXSID50376449
Nikkaji Number:J2.879.611K
Wikidata:Q72480048
Mol file:174669-74-0.mol

Synonyms:2-Fluoro-3-hydroxypyridine;174669-74-0;2-fluoropyridin-3-ol;2-Fluoro-3-pyridinol;3-Pyridinol, 2-fluoro-;2-Fluoropyridine-3-ol;MFCD04112569;3-hydroxy-2-fluoropyridine;SCHEMBL323239;DTXSID50376449;UEQRKEWMEMJXQO-UHFFFAOYSA-N;BBL101099;STL554893;AKOS005256747;AC-6004;CS-W019913;PS-9241;SB40454;2-Fluoro-3-hydroxypyridine, AldrichCPR;SY014301;A3862;AM20050884;F0886;FT-0646954;EN300-104296;J-509368;Z1198164106

Suppliers and Price of 2-Fluoro-3-hydroxypyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Fluoro-3-hydroxypyridine
10g
$ 690.00

TCI Chemical
2-Fluoro-3-hydroxypyridine >98.0%(GC)(T)
5g
$ 440.00

TCI Chemical
2-Fluoro-3-hydroxypyridine >98.0%(GC)(T)
1g
$ 129.00

SynQuest Laboratories
2-Fluoro-3-hydroxypyridine
25 g
$ 141.00

SynQuest Laboratories
2-Fluoro-3-hydroxypyridine
100 g
$ 464.00

SynQuest Laboratories
2-Fluoro-3-hydroxypyridine
5 g
$ 40.00

Matrix Scientific
2-Fluoro-3-hydroxypyridine 98%
25g
$ 120.00

Matrix Scientific
2-Fluoro-3-hydroxypyridine 98%
5g
$ 35.00

Frontier Specialty Chemicals
2-Fluoropyridin-3-ol 98%
5g
$ 20.00

Frontier Specialty Chemicals
2-Fluoropyridin-3-ol 98%
1g
$ 5.00

Total 93 raw suppliers

Chemical Property of 2-Fluoro-3-hydroxypyridine

Chemical Property:

Appearance/Colour:light yellow cryst
Vapor Pressure:0.000418mmHg at 25°C
Melting Point:131-133°C
Refractive Index:1.526
Boiling Point:306.7 °C at 760 mmHg
PKA:4.92±0.10(Predicted)
Flash Point:139.3 °C
PSA：33.12000
Density:1.325 g/cm³
LogP:0.92630
Storage Temp.:Room temperature.
Solubility.:DMSO, Methanol
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:113.027691913
Heavy Atom Count:8
Complexity:78.8

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-3-hydroxypyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,Xn
Statements: 22-36/37/38
Safety Statements: 26-37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(N=C1)F)O
Uses As a pyridine derivative, 2-Fluoro-3-hydroxypyridine can be used in the preparation of imaging agents for nicotinic α4β2 receptor. A pyridine derivative used in the preparation of imaging agents for nicotinic α4β2 receptor.

Technology Process of 2-Fluoro-3-hydroxypyridine

There total 8 articles about 2-Fluoro-3-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 372-48-5
2-fluoropyridine

: 174669-74-0
2-fluoro-3-hydroxypyridine

Guidance literature:: 2-fluoropyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃;

With Trimethyl borate; In tetrahydrofuran; hexane; for 2h;

With peracetic acid; In tetrahydrofuran; hexane; water; acetic acid; at 0 ℃; for 1h;

Reference yield: 65.0%

: 16867-03-1
2-amino-3-hydroxypyridine

: 174669-74-0
2-fluoro-3-hydroxypyridine

Guidance literature:: 2-amino-3-hydroxypyridine; With pyridine; hydrogen fluoride; sodium nitrite; at 0 ℃; for 1h;

With sodium hydroxide; water;

Reference yield: 62.0%

: 113975-22-7
2-fluoro-3-iodopyridine

: 174669-74-0
2-fluoro-3-hydroxypyridine

Guidance literature:: With copper(I) oxide; water; potassium carbonate; Sucrose; at 140 ℃; for 6h; Sealed tube; Inert atmosphere;
DOI:10.1039/d0ob01683g