6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

Base Information

• Chemical Name: 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
• CAS No.: 24248-74-6
• Molecular Formula: C₁₀H₁₃N₃O₂S
• Molecular Weight: 239.298
• Hs Code.: 2934999090
• Mol file: 24248-74-6.mol

Synonyms:6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide;6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide dihydrochlorid;6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide(SALTDATA: FREE);6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide dihydrochloride

Chemical Property of 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

Chemical Property:

• Melting Point: 250-252 °C
• Boiling Point: 450.4±45.0 °C(Predicted)
• PKA: 15.38±0.20(Predicted)
• PSA: 117.66000
• Density: 1.415±0.06 g/cm3(Predicted)
• LogP: 1.55320

Purity/Quality:

98% ^*data from raw suppliers

6-Acetyl-2-amino-4,5,6,7-tetrahydrothieno-[2,3-c]pyridine-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

There total 2 articles about 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-acetyl-4-piperidinone (32161-06-1) + cyanoacetic acid amide (107-91-5) → 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide (24248-74-6)

Guidance literature:

With sulfur; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00332-3

Reference yield:

→ 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide (24248-74-6)

Guidance literature:

entspr. 4-Piperidon, S, NCCH2CONH2;

Reference yield:

4-methoxy-benzaldehyde (123-11-5) + 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide (24248-74-6) → 7-Acetyl-2-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one

Guidance literature:

With hydrogenchloride; In butan-1-ol; at 80 ℃; for 10h;

DOI:10.1016/j.bmcl.2005.07.072

upstream raw materials:

1-acetyl-4-piperidinone

cyanoacetic acid amide

Refernces

• 1、 Fujita, Masakazu,Seki, Taketsugu,Ikeda, Naoko. "Synthesis and bioactivities of novel bicyclic thiophenes and 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.". . p. 1897 - 1900. Retrieved 2007/10/03.