ETHYL 5-OXO-5-(2-PYRIDYL)VALERATE

Base Information

• Chemical Name: ETHYL 5-OXO-5-(2-PYRIDYL)VALERATE
• CAS No.: 898776-54-0
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.256
• Hs Code.: 2933399090
• Mol file: 898776-54-0.mol

Synonyms:ETHYL 5-OXO-5-(2-PYRIDYL)VALERATE

Chemical Property of ETHYL 5-OXO-5-(2-PYRIDYL)VALERATE

Chemical Property:

• Vapor Pressure: 6.04E-05mmHg at 25°C
• Boiling Point: 345.7°C at 760 mmHg
• Flash Point: 162.9°C
• PSA: 56.26000
• Density: 1.105g/cm³
• LogP: 1.99770

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-oxo-5-(2-pyridyl)valerate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ETHYL 5-OXO-5-(2-PYRIDYL)VALERATE

There total 5 articles about ETHYL 5-OXO-5-(2-PYRIDYL)VALERATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethanol (64-17-5) + 5-(2-pyridyl)-5-oxopentanoic acid (13672-84-9) → ethyl 5-oxo-5-(pyridin-2-yl)pentanoate (898776-54-0)

Guidance literature:

With sulfuric acid; at 85 ℃;

DOI:10.1016/j.bmcl.2013.01.121

Reference yield: 75.0%

1-(2-pyridyl)-3-(2-pyridyl)-1,3-propanedione (10198-89-7) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 5-oxo-5-(pyridin-2-yl)pentanoate (898776-54-0)

Guidance literature:

With potassium carbonate; In ethanol; at 85 ℃; Sealed tube;

DOI:10.1039/c5ob02570b

Reference yield:

glutaric anhydride, (108-55-4) → ethyl 5-oxo-5-(pyridin-2-yl)pentanoate (898776-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -78 °C

1.2: -78 - 20 °C

2.1: sulfuric acid / 7 h / Reflux

With n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane;

DOI:10.1002/anie.201303011

upstream raw materials:

ethanol

5-(2-pyridyl)-5-oxopentanoic acid

glutaric anhydride,

5-hydroxy-1(pyridin-2-yl)pentan-1-one

Refernces

• 1、 Cai, Gui-Xin,Wen, Jing,Lai, Ting-Ting,Xie, Dan,Zhou, Cheng-He. "Sequential Michael addition/retro-Claisen condensation of aromatic β-diketones with α,β-unsaturated esters: An approach to obtain 1,5-ketoesters". supporting information. p. 2390 - 2394. Retrieved 2016/03/01.
• 2、 Yang, Xiao-Hui,Xie, Jian-Hua,Liu, Wei-Peng,Zhou, Qi-Lin. "Catalytic asymmetric hydrogenation of δ-ketoesters: Highly efficient approach to chiral 1,5-diols". . p. 7833 - 7836. Retrieved 2013/08/23.