Ingenol Disoxate

Base Information

• Chemical Name: Ingenol Disoxate
• CAS No.: 1333386-17-6
• Molecular Formula: C₇H₈O₃S*C₂₁H₁₆ClF₃N₄O₃
• Molecular Weight: 640.012
• Mol file: 1333386-17-6.mol

Synonyms:Ingenol Disoxate

Chemical Property of Ingenol Disoxate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ingenol Disoxate

There total 16 articles about Ingenol Disoxate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d3)aminoformyl)-4-pyridyloxy)phenyl)urea (1130115-44-4) + toluene-4-sulfonic acid (104-15-4) → 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxyl)-2-(N-1’,1’,1’-trideuteromethyl)pyridine amide p-toluenesulfonate (1333386-17-6)

Guidance literature:

In ethanol; at 70 - 78 ℃; for 1.66667h;

Reference yield:

4-chloropyridinyl-2-(N-1',1',1'-trideuteromethylcarboxamide) (1189858-48-7) → 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxyl)-2-(N-1’,1’,1’-trideuteromethyl)pyridine amide p-toluenesulfonate (1333386-17-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 80 °C

2.1: dichloromethane / 16 h / 20 °C

2.2: 18 h / 20 °C

3.1: ethanol / 1.67 h / 70 - 78 °C

With potassium tert-butylate; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

4-chloro-pyridine-2-carbonyl chloride (53750-66-6) → 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxyl)-2-(N-1’,1’,1’-trideuteromethyl)pyridine amide p-toluenesulfonate (1333386-17-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 5 h / 5 °C / Cooling with ice

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 80 °C

3.1: dichloromethane / 16 h / 20 °C

3.2: 18 h / 20 °C

4.1: ethanol / 1.67 h / 70 - 78 °C

With potassium tert-butylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-chloro-pyridine-2-carbonyl chloride

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d₃)aminoformyl)-4-pyridyloxy)phenyl)urea

toluene-4-sulfonic acid

2-Picolinic acid

Refernces

• 1、 -. "POLYMORPHS OF DEUTERATED OMEGA-DIPHENYLUREA OR SALTS THEREOF". Paragraph 0157-0160. . Retrieved 2015/11/16.
• 2、 -. "METHOD FOR PREPARING DEUTERATED DIPHENYLUREA". . . Retrieved 2013/03/26.