6-BroMo-3-fluoroisoquinoline

Base Information

• Chemical Name: 6-BroMo-3-fluoroisoquinoline
• CAS No.: 891785-30-1
• Molecular Formula: C9H5BrFN
• Molecular Weight: 226.048
• Hs Code.: 2933499090
• Mol file: 891785-30-1.mol

Synonyms:6-BroMo-3-fluoroisoquinoline

Chemical Property of 6-BroMo-3-fluoroisoquinoline

Chemical Property:

• Boiling Point: 326.4±22.0 °C(Predicted)
• PKA: 1.02±0.38(Predicted)
• PSA: 12.89000
• Density: 1.647±0.06 g/cm3(Predicted)
• LogP: 3.13640
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

6-Bromo-3-fluoroisoquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BroMo-3-fluoroisoquinoline

There total 3 articles about 6-BroMo-3-fluoroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-bromo-isoquinolin-3-ylamine (891785-28-7) → 6-bromo-3-fluoro-isoquinoline (891785-30-1)

Guidance literature:

6-bromo-isoquinolin-3-ylamine; With sodium nitrite;

With pyridine; hydrogen fluoride;

DOI:10.1016/j.bmcl.2006.03.041

Reference yield:

6-bromo-3-chloro-isoquinoline (552331-06-3) → 6-bromo-3-fluoro-isoquinoline (891785-30-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 42 percent / NaH / dimethylformamide

2.1: 66 percent / CF₃COOH / Heating

3.1: NaNO₂

3.2: 92 percent / HF; pyridine

With sodium hydride; trifluoroacetic acid; sodium nitrite; In N,N-dimethyl-formamide; 3.2: Sandmeyer reaction;

DOI:10.1016/j.bmcl.2006.03.041

Reference yield:

benzyl-(6-bromo-isoquinolin-3-yl)-amine (934343-53-0) → 6-bromo-3-fluoro-isoquinoline (891785-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 66 percent / CF₃COOH / Heating

2.1: NaNO₂

2.2: 92 percent / HF; pyridine

With trifluoroacetic acid; sodium nitrite; 2.2: Sandmeyer reaction;

DOI:10.1016/j.bmcl.2006.03.041

upstream raw materials:

6-bromo-isoquinolin-3-ylamine

6-bromo-3-chloro-isoquinoline

benzyl-(6-bromo-isoquinolin-3-yl)-amine

Downstream raw materials:

3-fluoroisoquinolin-6-ylboronic acid

6-bromo-N-(1,3-dimethyl-1H-pyrazol-5-yl)-isoquinolin-3-amine

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