4-[(DIMETHYLAMINO)METHYLENE]-2-PHENYL-1,3-OXAZOL-5(4H)-ONE

Base Information

• Chemical Name: 4-[(DIMETHYLAMINO)METHYLENE]-2-PHENYL-1,3-OXAZOL-5(4H)-ONE
• CAS No.: 51254-00-3
• Molecular Formula: C12H12 N2 O2
• Molecular Weight: 216.24
• Hs Code.: 2934999090
• Mol file: 51254-00-3.mol

Synonyms:4-[(DIMETHYLAMINO)METHYLENE]-2-PHENYL-1,3-OXAZOL-5(4H)-ONE

Chemical Property of 4-[(DIMETHYLAMINO)METHYLENE]-2-PHENYL-1,3-OXAZOL-5(4H)-ONE

Chemical Property:

• Vapor Pressure: 0.00277mmHg at 25°C
• Melting Point: 166-169°C
• Boiling Point: 285.6°Cat760mmHg
• Flash Point: 126.5°C
• PSA: 41.90000
• Density: 1.16g/cm³
• LogP: 0.82860

Purity/Quality:

97% ^*data from raw suppliers

4-[(Dimethylamino)methylene]-2-phenyl-1,3-oxazol-5(4H)-one >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(DIMETHYLAMINO)METHYLENE]-2-PHENYL-1,3-OXAZOL-5(4H)-ONE

There total 19 articles about 4-[(DIMETHYLAMINO)METHYLENE]-2-PHENYL-1,3-OXAZOL-5(4H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-( N,N-dimethylaminomethylene)-2-phenyl-2-oxazolin-5-one (51254-00-3)

Guidance literature:

With trichlorophosphate; 1.) -20 deg C, 30 min, 2.) 45-50 deg C, 3 h.;

DOI:10.1007/BF00475385

Reference yield: 90.0%

hippurylanilide (3106-11-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-( N,N-dimethylaminomethylene)-2-phenyl-2-oxazolin-5-one (51254-00-3)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 0.333333h;

Reference yield: 85.0%

Benzoylamino-acetic acid sec-butyl ester (106275-09-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-( N,N-dimethylaminomethylene)-2-phenyl-2-oxazolin-5-one (51254-00-3)

Guidance literature:

With trichlorophosphate; at 90 ℃; for 0.5h;

upstream raw materials:

Hippuric Acid

N,N-dimethyl-formamide

2-ethoxycarbonyl-1-cyclopentanone

methyl 2-N-benzoylamino-3-N,N-dimethylamino-2-propenoate

Downstream raw materials:

4-benzylidene-2-phenyloxazole-5(4H)-one

methyl (Z)-2-benzoylamino-3-dimethylaminopropenoate