Urea, N-(2-broMo-6-fluorophenyl)-N'-[2-Methoxy-5-(trifluoroMethyl)phenyl]-

Base Information

Chemical Name:Urea, N-(2-broMo-6-fluorophenyl)-N'-[2-Methoxy-5-(trifluoroMethyl)phenyl]-
CAS No.:917389-23-2
Molecular Formula:C15H11BrF4N2O2
Molecular Weight:407.1576528
Hs Code.:
Mol file:917389-23-2.mol

Synonyms:Urea, N-(2-broMo-6-fluorophenyl)-N'-[2-Methoxy-5-(trifluoroMethyl)phenyl]-

Suppliers and Price of Urea, N-(2-broMo-6-fluorophenyl)-N'-[2-Methoxy-5-(trifluoroMethyl)phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 19 raw suppliers

Chemical Property of Urea, N-(2-broMo-6-fluorophenyl)-N'-[2-Methoxy-5-(trifluoroMethyl)phenyl]-

Chemical Property:

Boiling Point:341.8±42.0 °C(Predicted)
PKA:12.13±0.70(Predicted)
PSA：50.36000
Density:1.643±0.06 g/cm3(Predicted)
LogP:5.40560

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of Urea, N-(2-broMo-6-fluorophenyl)-N'-[2-Methoxy-5-(trifluoroMethyl)phenyl]-

There total 2 articles about Urea, N-(2-broMo-6-fluorophenyl)-N'-[2-Methoxy-5-(trifluoroMethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

: 16588-75-3
2-methoxy-5-trifluoromethylphenyl isocyanate

: 65896-11-9
2-bromo-6-fluoroaniline

: 917389-23-2
3-(2-bromo-6-fluorophenyl)-1-[2-methoxy-5-(trifluoromethyl)phenyl]urea

Guidance literature:: In acetonitrile; at 35 - 88 ℃; for 38 - 45h; Product distribution / selectivity;

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 349-65-5
2-Methoxy-5-trifluoromethyl-aniline

: 65896-11-9
2-bromo-6-fluoroaniline

: 917389-23-2
3-(2-bromo-6-fluorophenyl)-1-[2-methoxy-5-(trifluoromethyl)phenyl]urea

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; for 3h; Inert atmosphere;

Reference yield:

: 917389-23-2
3-(2-bromo-6-fluorophenyl)-1-[2-methoxy-5-(trifluoromethyl)phenyl]urea

: 791116-51-3
(+/-)-{8-fluoro-2-[4-(3-methoxyphenyl)-piperazin-1-yl]-3-[2-methoxy-5-trifluoromethyl-phenyl]-3,4-dihydro-quinazolin-4-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloro bis(acetonitrile) palladium(II); tris-(o-tolyl)phosphine / Isobutyronitrile / 16 - 22 h / 90 - 102 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / chlorobenzene / 9.17 - 9.33 h / 120 - 130 °C / Heating / reflux

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane; chlorobenzene / 22 h / 20 °C / Heating / reflux

4: sodium hydroxide; water / 1,4-dioxane / 2 h / 20 °C

With sodium hydroxide; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trichlorophosphate; dichloro bis(acetonitrile) palladium(II); tris-(o-tolyl)phosphine; In 1,4-dioxane; Isobutyronitrile; chlorobenzene;