7-bromo-3-fluoroquinoline

Base Information

• Chemical Name: 7-bromo-3-fluoroquinoline
• CAS No.: 1375108-29-4
• Molecular Formula: C9H5BrFN
• Molecular Weight: 226.048
• Mol file: 1375108-29-4.mol

Synonyms:7-bromo-3-fluoroquinoline

Chemical Property of 7-bromo-3-fluoroquinoline

Chemical Property:

• Boiling Point: 299.7±20.0 °C(Predicted)
• PKA: 0.73±0.25(Predicted)
• PSA: 12.89000
• Density: 1.647±0.06 g/cm3(Predicted)
• LogP: 3.13640

Purity/Quality:

97% ^*data from raw suppliers

7-Bromo-3-fluoroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-bromo-3-fluoroquinoline

There total 5 articles about 7-bromo-3-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

7-bromoquinolin-3-amine (1266322-58-0) → 7-bromo-3-fluoroquinoline (1375108-29-4)

Guidance literature:

With tert.-butylnitrite; boron trifluoride dihydrate; In chlorobenzene; at 50 - 100 ℃; for 2h; Inert atmosphere;

Reference yield:

2-(7-bromoquinolin-3-yl)isoindoline-1,3-dione (1375108-38-5) → 7-bromo-3-fluoroquinoline (1375108-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / ethanol / 1 h / Reflux

2: boron trifluoride dihydrate; tert.-butylnitrite / chlorobenzene / 0.83 h / 50 - 100 °C

With tert.-butylnitrite; boron trifluoride dihydrate; hydrazine; In ethanol; chlorobenzene;

Reference yield:

2-amino-4-bromobenzaldehyde (59278-65-8) → 7-bromo-3-fluoroquinoline (1375108-29-4)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene / Reflux; Dean-Stark

2: hydrazine / ethanol / 1 h / Reflux

3: boron trifluoride dihydrate; tert.-butylnitrite / chlorobenzene / 0.83 h / 50 - 100 °C

With tert.-butylnitrite; boron trifluoride dihydrate; toluene-4-sulfonic acid; hydrazine; In ethanol; chlorobenzene; toluene;

upstream raw materials:

2-(7-bromoquinolin-3-yl)isoindoline-1,3-dione

7-bromoquinolin-3-amine

2-amino-4-bromobenzaldehyde

2-amino-4-bromo-benzoic acid methyl ester

Downstream raw materials:

(S)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one