(S)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

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Chemical Name:(S)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one
CAS No.:1619968-86-3
Molecular Formula:C₂₅H₂₃F₂N₅O₂
Molecular Weight:463.487
Hs Code.:

Synonyms:(S)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

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Chemical Property of (S)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

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Technology Process of (S)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

There total 11 articles about (S)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1332333-90-0
4-(4-bromo-2-fluorophenyl)-5-{[(3S)-1-propanoyl-3-pyrrolidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1375108-29-4
7-bromo-3-fluoroquinoline

: 1619968-86-3
(S)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: 7-bromo-3-fluoroquinoline; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere;

4-(4-bromo-2-fluorophenyl)-5-{[(3S)-1-propanoyl-3-pyrrolidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one; With potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1375108-38-5
2-(7-bromoquinolin-3-yl)isoindoline-1,3-dione

: 1619968-86-3
(S)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine / ethanol / 1 h / Reflux

2.1: boron trifluoride dihydrate; tert.-butylnitrite / chlorobenzene / 2 h / 50 - 100 °C / Inert atmosphere

3.1: potassium acetate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

3.2: 2 h / 100 °C / Inert atmosphere

With tert.-butylnitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; boron trifluoride dihydrate; potassium acetate; bis(pinacol)diborane; hydrazine; In 1,4-dioxane; ethanol; chlorobenzene;

Reference yield:

: 1266322-58-0
7-bromoquinolin-3-amine

: 1619968-86-3
(S)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trifluoride dihydrate; tert.-butylnitrite / chlorobenzene / 2 h / 50 - 100 °C / Inert atmosphere

2.1: potassium acetate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

2.2: 2 h / 100 °C / Inert atmosphere

With tert.-butylnitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; boron trifluoride dihydrate; potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; chlorobenzene;