Phosphoric acid (potassium)

Base Information

• Chemical Name: Phosphoric acid (potassium)
• CAS No.: 7778-53-2
• Molecular Formula: K3O4P
• Molecular Weight: 212.27
• Hs Code.: 2835240000
• Mol file: 7778-53-2.mol

Synonyms:Phosphoric acid (potassium);PJNZPQUBCPKICU-UHFFFAOYSA-N;Potassium phosphate monobasic, 99.0%;Potassium phosphate monobasic, >=99.5%;Potassium phosphate monobasic, LR, >=98%;Potassium phosphate monobasic, ReagentPlus(R);Potassium phosphate monobasic, NIST SRM 2186I;Potassium phosphate monobasic, AR, 99.5-100.5%;Potassium phosphate monobasic, USP, 98.0-100.5%;Potassium dihydrogen phosphate, NIST(R) SRM(R) 200b;Potassium phosphate monobasic, ACS reagent, >=99.0%;Potassium phosphate monobasic, for HPLC, 99.5-100.5%;Potassium phosphate monobasic, 99.99% trace metals basis;Potassium phosphate monobasic, JIS special grade, >=99.0%;Potassium phosphate monobasic, SAJ first grade, >=99.0%;Potassium phosphate monobasic, for molecular biology, >=98.0%;Potassium phosphate monobasic, Vetec(TM) reagent grade, 99%;Potassium phosphate monobasic, plant cell culture tested, >=99%;Potassium phosphate monobasic, p.a., ACS reagent, reag. ISO, 99.5%;Potassium phosphate monobasic, suitable for oxidant determination, >=99.0%;Potassium phosphate monobasic, tested according to Ph.Eur., anhydrous;Monobasic potassium phosphate, United States Pharmacopeia (USP) Reference Standard;Potassium phosphate monobasic, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99%;Potassium phosphate monobasic, BioUltra, for molecular biology, anhydrous, >=99.5% (T);Monobasic Potassium Phosphate, Pharmaceutical Secondary Standard;Certified Reference Material;Potassium phosphate monobasic, anhydrous, free-flowing, Redi-Dri(TM), ReagentPlus(R), >=99.0% (titration);Potassium phosphate monobasic, buffer substance, anhydrous, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 99.5-100.5%;Potassium phosphate monobasic, powder, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, >=99.0%;Potassium phosphate monobasic, TraceCERT(R), certified reference material, 31P-qNMR Standard

Chemical Property of Phosphoric acid (potassium)

Chemical Property:

• Appearance/Colour: white powder or crystals
• Melting Point: 1340 °C
• Boiling Point: 158 °C at 760 mmHg
• PSA: 96.06000
• Density: 2.564 g/mL at 25 °C(lit.)
• LogP: 0.38600
• Water Solubility.: 50.8 g/100 mL (25℃)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 136.94060206
• Heavy Atom Count: 6
• Complexity: 49.8

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): C, Xi
• Hazard Codes: Xi:Irritant
• Statements: R38:; R41:
• Safety Statements: S26:; S39:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: OP(=O)(O)O.[K]
• General Description: Potassium orthophosphate (K?PO?), also known as tripotassium phosphate, is a tribasic inorganic salt widely used as a base in organic synthesis. It facilitates reactions such as the one-pot synthesis of 2-oxazolines from ethyl α-cyanocinnamate derivatives, copper-catalyzed annulations, and Ni-catalyzed arylations of α-halocarbonyl compounds, often under mild conditions with good to excellent yields. Its role as a mild, non-nucleophilic base makes it suitable for diverse transformations, including asymmetric syntheses and regioselective additions, while maintaining compatibility with functional groups and aqueous or organic solvents.

Refernces

Efficient ligand-free copper-catalyzed N-arylation of amides with aryl halides in water

10.1016/j.tetlet.2011.01.003

The study develops an efficient and environmentally friendly method for the N-arylation of amides using aryl halides, catalyzed by ligand-free copper(I) oxide (Cu2O) in water. This method provides a practical approach to synthesizing N-arylated amides, which are valuable in pharmaceuticals and materials science. The research focuses on optimizing reaction conditions, including the choice of copper catalyst, base, and phase-transfer catalyst, to achieve good to excellent yields of the desired N-arylated products. The method proves effective for a variety of amides and aryl iodides, making it a versatile tool for organic synthesis.

One-pot synthesis of 2-oxazolines from ethyl α-cyanocinnamate derivatives with n-bromoacetamide

10.1002/jhet.1902

The research focuses on the development of an efficient one-pot synthesis method for 2-oxazoline derivatives from ethyl α-cyanocinnamate derivatives using N-bromoacetamide (NBA) and potassium phosphate (K3PO4) as the base. The study was conducted at room temperature in acetone without the need for inert gas protection. The reaction yields were good to excellent (up to 98%) and were completed within 4.5 hours. A total of 13 examples were investigated, and the substrates were varied to include electron-donating and electron-withdrawing groups to assess the reaction's scope and limitations. The analysis involved monitoring the reaction progress using thin-layer chromatography (TLC) and determining the structures of the products through nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). The reaction mechanism was proposed based on the observed intermediates and the regioselectivity of the reaction, involving an aminobrominated intermediate and a cyclization process. The research also included the preparation of single crystals for X-ray crystallographic analysis to confirm the regiospecifity of the 2-oxazoline products.

Copper-catalyzed annulation of 2-formylazoles with o-aminoiodoarenes

10.1021/jo9025644

The research focuses on the development of a copper-catalyzed annulation reaction between 2-formylazoles and o-aminoiodoarenes, leading to the synthesis of substituted pyrrolo[1,2-a]quinoxalines and related heterocycles. This method provides a one-step route to these biologically active molecules, which are present in a growing number of pharmaceutical compounds. The reaction conditions were optimized using 2-iodoaniline and 2-formylpyrrole as starting materials, with the best results obtained using 1 equivalent of 2-formylpyrrole, 1.5 equivalents of 2-iodoaniline, 2 equivalents of K3PO4, 10 mol % CuI, 20 mol % sparteine, and NMP as the solvent at 130°C for 24 hours. The reaction was found to be effective for a variety of substituted aminoiodoarenes and formylazoles, including 2-formylimidazole, 2-formylbenzimidazole, and a 3-formylpyrazole. The synthesized products were analyzed using techniques such as high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry (HRMS) to confirm their structures and purities.

Ni-catalyzed mild arylation of α-halocarbonyl compounds with arylboronic acids

10.1021/ol702456z

The research focuses on the development of a Ni-catalyzed mild arylation process for the direct arylations of α-halocarbonyl compounds, including esters, amides, and ketones, with various arylboronic acids. The purpose of this study was to create a method that is complementary to the well-established Buchwald?Hartwig approach, offering greater synthetic flexibility and functional group tolerance. The researchers discovered that Ni(PPh3)4 served as a highly effective catalyst, leading to the formation of a wide variety of arylated carbonyl compounds with good to excellent yields. Compared to Pd-catalyzed arylations using aryl halides, the Ni-based catalysis approach demonstrated advantages in terms of functional group tolerance and reaction selectivity. Key chemicals used in the process include α-halocarbonyl compounds, arylboronic acids, and Ni(PPh3)4 as the catalyst, with K3PO4 as a base. The method was found to be simple, general, and practical, holding promise for the preparation of structurally diverse arylated carbonyl compounds.

Enantioselective synthesis of C₂-symmetric spirobilactams via Pd-catalyzed intramolecular double N-arylation

10.1021/ol900016g

The study presents an enantioselective synthesis method for C2-symmetric spirobilactams, which are important in synthetic chemistry due to their rigid spiro backbone that creates an effective asymmetric environment. The researchers used a Pd/BINAP complex as a catalyst to achieve an intramolecular double N-arylation of malonamides bearing 2-bromoarylmethyl groups, resulting in C2-symmetric spirobi(3,4-dihydro-2-quinolone) derivatives with up to 70% enantiomeric excess (ee). Key chemicals involved in the study include malonamides, bromoarenes, Pd(OAc)2 as the palladium source, (S)-BINAP as the chiral ligand, and various bases and solvents such as Cs2CO3, K3PO4, and DMPU. These chemicals served the purpose of facilitating the catalytic asymmetric synthesis, which is a highly practical method for preparing optically active spiranes, potentially useful as ligands and organocatalysts.

Determination of plasma levels of the active thiol form of the direct-acting PrC-210 ROS-scavenger using a fluorescence-based assay

10.1016/j.ab.2021.114100

The research focuses on the development and validation of a fluorescence-based assay for determining the levels of the active thiol form of PrC-210, a direct-acting ROS-scavenger, in blood plasma. The study details experiments involving the reaction of PrC-210 with monochlorobimane to form a stable, fluorescent adduct, which is then quantified using a fluorescence plate reader. The reactants used include PrC-210, monochlorobimane, potassium phosphate buffer, and various biological samples such as plasma and whole blood from rats. The analyses encompass the optimization of reaction conditions, pH dependence, the stability of the adduct, and the assay's sensitivity and specificity. The experiments also investigate the processing of blood samples, the fate of PrC-210 in plasma and whole blood, and its radioprotective effects in mice. The assay's accuracy was validated through spiked samples, and its practical application was demonstrated by measuring PrC-210 levels in plasma post-irradiation, showcasing its potential for use in human clinical settings.

Highly regioselective introduction of aryl substituents via asymmetric 1,4-addition of boronic acids to linear α,β,γ,δ-unsaturated ketones

10.1055/s-0035-1560513

The research aims to develop an efficient and regioselective asymmetric 1,4-conjugate addition of arylboronic acids to linear α,β,γ,δ-unsaturated ketones using phosphapalladacycle catalysts. The study successfully developed a palladium(II)-catalyzed method that allows for the exclusive formation of 1,4-products with perfect regioselectivity, appreciable yields, and enantioselectivities. The protocol is tolerant of a wide range of dienone substrates and substituted arylboronic acids, and can be conducted at room temperature using air- and moisture-stable reagents. Key chemicals used in the process include arylboronic acids, linear α,β,γ,δ-unsaturated ketones, palladium catalysts, and K3PO4 as a base in toluene as the solvent.

Copper-Catalyzed Synthesis and Applications of Yndiamides

10.1002/anie.201706915

The research explores the first synthetic route to yndiamides, a novel class of double aza-substituted alkynes, via copper (I)-catalyzed cross-coupling of 1,1-dibromoenamides with nitrogen nucleophiles. The study aims to develop a method for preparing yndiamides and investigate their unique reactivity and potential applications in organic synthesis. The researchers optimized the coupling conditions using copper sulfate pentahydrate, 1,10-phenanthroline, and potassium phosphate, achieving high yields of yndiamides. They demonstrated the versatility of yndiamides in various transformations, including palladium-catalyzed cycloisomerizations, rhodium-catalyzed [5+2] cycloisomerizations, Pauson-Khand reactions, and Br?nsted acid-catalyzed reactions, yielding a wide range of 1,2-diamide functionalized products. The study concludes that yndiamides are valuable components in azacycle synthesis and exhibit distinct reactivity compared to ynamides, suggesting significant potential for future applications.