One-pot synthesis of 2-oxazolines from ethyl α-cyanocinnamate derivatives with n-bromoacetamide

Article abstract of DOI:10.1002/jhet.1902

An efficient method for the one-pot synthesis of 2-oxazolines from ethyl α-cyanocinnamate derivatives with N-bromoacetamide in the presence of K₃PO₄ has been developed. The reaction performed smoothly and cleanly to give 2-oxazolines in good to excellent yields (up to 98%) within 4.5 h in acetone at room temperature without protection of inert gases. A total of 13 examples have been investigated. A possible nucleophilic addition reaction mechanism is proposed.