5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one

Base Information

Chemical Name:5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one
CAS No.:875071-97-9
Molecular Formula:C10H8BrNO
Molecular Weight:238.084
Hs Code.:2933990090
Mol file:875071-97-9.mol

Synonyms:5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one;5'-bromo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2'-one

Suppliers and Price of 5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one 95+%
1g
$ 436.00

Chemenu
5''-Bromospiro[cyclopropane-1,3''-indolin]-2''-one 95%
1g
$ 463.00

Biosynth Carbosynth
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one
500 mg
$ 315.00

Biosynth Carbosynth
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one
250 mg
$ 182.50

Biosynth Carbosynth
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one
100 mg
$ 91.00

Biosynth Carbosynth
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one
50 mg
$ 52.00

Biosynth Carbosynth
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one
1 g
$ 550.00

American Custom Chemicals Corporation
5'-BROMOSPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONE 95.00%
5MG
$ 498.74

Alichem
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one
1g
$ 573.30

AK Scientific
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one
100mg
$ 172.00

Total 23 raw suppliers

Chemical Property of 5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one

Chemical Property:

PSA：29.10000
LogP:2.57080
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 5''-Bromospiro[cyclopropane-1,3''-indolin]-2''-one can be used as CDK8 inhibitor for the treatment of cancer.

Technology Process of 5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one

There total 6 articles about 5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 13861-75-1
spiro[cyclopropane-1,3'-indolin]-2'-one

: 875071-97-9
5'-bromospiro[cyclopropane-1,3'-indoline]-2'-one

Guidance literature:: With bromine; sodium acetate; acetic acid; In dichloromethane; for 4h;

Reference yield: 72.0%

: 20870-78-4
5-bromo-2-indolin-2-one

: 247129-85-7
(2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate

: 875071-97-9
5'-bromospiro[cyclopropane-1,3'-indoline]-2'-one

Guidance literature:: 5-bromo-2-indolin-2-one; (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/j.tet.2018.09.042

Reference yield: 48.0%

: 20870-78-4
5-bromo-2-indolin-2-one

: 106-93-4
ethylene dibromide

: 875071-97-9
5'-bromospiro[cyclopropane-1,3'-indoline]-2'-one

Guidance literature:: 5-bromo-2-indolin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -30 ℃; for 0.5h; Inert atmosphere;

ethylene dibromide; In tetrahydrofuran; hexane; at 20 ℃; for 18h; Inert atmosphere;