(R)-N-DeMethyl Dapoxetine

Base Information

Chemical Name:(R)-N-DeMethyl Dapoxetine
CAS No.:1202160-36-8
Molecular Formula:C20H21NO
Molecular Weight:291.38684
Hs Code.:
Mol file:1202160-36-8.mol

Synonyms:(R)-N-DeMethyl Dapoxetine;(αR)-N-Methyl-α-[2-(1-naphthalenyloxy)ethyl]benzeneMethanaMine

Suppliers and Price of (R)-N-DeMethyl Dapoxetine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-N-DemethylDapoxetine
10mg
$ 155.00

TRC
(R)-N-DemethylDapoxetine
100mg
$ 1230.00

American Custom Chemicals Corporation
(R)-N-DEMETHYL DAPOXETINE 95.00%
5MG
$ 498.54

Total 5 raw suppliers

Chemical Property of (R)-N-DeMethyl Dapoxetine

Chemical Property:

Boiling Point:459.5±38.0 °C(Predicted)
PKA:9.21±0.20(Predicted)
PSA：21.26000
Density:1.089±0.06 g/cm3(Predicted)
LogP:4.96030

Purity/Quality:

98% ^*data from raw suppliers

(R)-N-DemethylDapoxetine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses The (R)-metabolite of Dapoxetine (D185700). Selective serotonin reuptake inhibitor antidepressant The (R)-metabolite of Dapoxetine (D185700). Selective serotonin reuptake inhibitor antidepressant.

Technology Process of (R)-N-DeMethyl Dapoxetine

There total 1 articles about (R)-N-DeMethyl Dapoxetine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 90-15-3
α-naphthol

: 1202160-34-6
(R)-3-methyl-4-phenyl-[1,2,3]oxathiazinane 2,2-dioxide

: 1202160-36-8,147199-39-1
(R)-methyl-[3-(naphthalen-1-yloxy)-1-phenyl-propyl]-amine

Guidance literature:: α-naphthol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

(R)-3-methyl-4-phenyl-[1,2,3]oxathiazinane 2,2-dioxide; In N,N-dimethyl-formamide; at 20 ℃; for 1h; optical yield given as %ee; Further stages; Inert atmosphere;
DOI:10.1021/jo902176s

Reference yield: 79.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1202160-36-8,147199-39-1
(R)-methyl-[3-(naphthalen-1-yloxy)-1-phenyl-propyl]-amine

: 119357-36-7,119356-77-3
(R)-N,N-dimethyl-α-[2-(1-naphthyloxy)ethyl]benzylamine

Guidance literature:: formaldehyd; (R)-methyl-[3-(naphthalen-1-yloxy)-1-phenyl-propyl]-amine; With formic acid; In water; for 8h; Reflux; Inert atmosphere;

With hydrogenchloride; In water; pH=1; Inert atmosphere;

With sodium hydroxide; In water; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/jo902176s