R-Dapoxetine

Base Information

Chemical Name:R-Dapoxetine
CAS No.:119357-36-7
Molecular Formula:C21H23NO
Molecular Weight:305.42
Hs Code.:
Mol file:119357-36-7.mol

Synonyms:R-Dapoxetine;ent-Dapoxetine;(alphaR)-N,N-Dimethyl-alpha-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine

Suppliers and Price of R-Dapoxetine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of R-Dapoxetine

Chemical Property:

Boiling Point:454.4±38.0 °C(Predicted)
PKA:8.38±0.50(Predicted)
PSA：12.47000
Density:1.081±0.06 g/cm3(Predicted)
LogP:4.91160

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of R-Dapoxetine

There total 11 articles about R-Dapoxetine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: tert-butyl (R,E)-(3-(naphthalen-1-yloxy)-1-phenylallyl)carbamate

: 119357-36-7,119356-77-3
(R)-N,N-dimethyl-α-[2-(1-naphthyloxy)ethyl]benzylamine

Guidance literature:: tert-butyl (R,E)-(3-(naphthalen-1-yloxy)-1-phenylallyl)carbamate; With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; at 20 ℃;

With trifluoroacetic acid; In methanol; dichloromethane; at 20 ℃; for 1h;

With formaldehyd; In methanol; dichloromethane; water; for 16h;
DOI:10.1021/acs.orglett.5b01755

Reference yield: 91.2%

: 119357-36-7,119356-77-3
(R)-N,N-dimethyl-α-[2-(1-naphthyloxy)ethyl]benzylamine

Guidance literature:: In water; at 90 - 110 ℃; Inert atmosphere;

Reference yield: 79.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1202160-36-8,147199-39-1
(R)-methyl-[3-(naphthalen-1-yloxy)-1-phenyl-propyl]-amine

: 119357-36-7,119356-77-3
(R)-N,N-dimethyl-α-[2-(1-naphthyloxy)ethyl]benzylamine

Guidance literature:: formaldehyd; (R)-methyl-[3-(naphthalen-1-yloxy)-1-phenyl-propyl]-amine; With formic acid; In water; for 8h; Reflux; Inert atmosphere;

With hydrogenchloride; In water; pH=1; Inert atmosphere;

With sodium hydroxide; In water; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/jo902176s