R-(N-Boc)-piperidine-3-carboxylhydrazide

Base Information

• Chemical Name: R-(N-Boc)-piperidine-3-carboxylhydrazide
• CAS No.: 1002359-83-2
• Molecular Formula: C11H21N3O3
• Molecular Weight: 243.306
• Mol file: 1002359-83-2.mol

Synonyms:R-(N-Boc)-piperidine-3-carboxylhydrazide ;tert-butyl (3R)-3-(hydrazinecarbonyl)piperidine-1-carboxylate

Chemical Property of R-(N-Boc)-piperidine-3-carboxylhydrazide

Chemical Property:

• PSA: 84.66000
• LogP: 1.65250

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-Boc-piperidine-3-carboxylicacidhydrazide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of R-(N-Boc)-piperidine-3-carboxylhydrazide

There total 7 articles about R-(N-Boc)-piperidine-3-carboxylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(3R)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (194726-40-4) → (R)-3-(hydrazinecarbonyl)piperidine-1-carboxylic acid tert-butyl ester (1002359-83-2)

Guidance literature:

With hydrazine hydrate; at 120 - 125 ℃; for 5h;

Reference yield:

1-(tert-butyl)-3-methyl-(R)-piperidine-1,3-dicarboxylate (934423-10-6) → (R)-3-(hydrazinecarbonyl)piperidine-1-carboxylic acid tert-butyl ester (1002359-83-2)

Guidance literature:

With hydrazine hydrate; at 122 ℃; for 4h;

Reference yield:

hydrazine hydrate (7803-57-8,79785-97-0) + ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate (191599-51-6) → (R)-3-(hydrazinecarbonyl)piperidine-1-carboxylic acid tert-butyl ester (1002359-83-2)

Guidance literature:

In ethanol; at 85 ℃; for 16h; Inert atmosphere;

upstream raw materials:

(3R)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

(R)-1-Boc-nipecotic acid

hydrazine hydrate

ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate

Downstream raw materials:

(R)-tert-butyl 3-(3-(3-bromo-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate

C₅₇H₅₁BrN₆O₂

(R)-tert-butyl 3-(3-(3-(pyridin-4-yl)-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate

(R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole

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