(R)-1-tert-butyl 3-methyl piperidine-1,3-dicarboxylate

Base Information

• Chemical Name: (R)-1-tert-butyl 3-methyl piperidine-1,3-dicarboxylate
• CAS No.: 934423-10-6
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.303
• Mol file: 934423-10-6.mol

Synonyms:(R)-1-Boc-piperidine-3-carboxylate methyl ester;(R)-1-Boc-piperidine-3-carboxylic acid methyl ester;(R)-1-tert-butyl 3-methyl piperidine-1,3-dicarboxylate;(R)-N-Boc-piperidine-3-carboxylate methyl ester;(R)-N-Boc-piperidine-3-carboxylic acid methyl ester

Chemical Property of (R)-1-tert-butyl 3-methyl piperidine-1,3-dicarboxylate

Chemical Property:

• Boiling Point: 307.4±35.0 °C(Predicted)
• PKA: -2.48±0.40(Predicted)
• PSA: 55.84000
• Density: 1.094±0.06 g/cm3(Predicted)
• LogP: 1.74440

Purity/Quality:

99%, ^*data from raw suppliers

(R)-Methyl1-boc-piperidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-tert-butyl 3-methyl piperidine-1,3-dicarboxylate

There total 2 articles about (R)-1-tert-butyl 3-methyl piperidine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-Boc-nipecotic acid (163438-09-3) + methyl iodide (74-88-4) → 1-(tert-butyl)-3-methyl-(R)-piperidine-1,3-dicarboxylate (934423-10-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (R)-piperidine-3-carboxylic acid methyl ester (164323-85-7) → 1-(tert-butyl)-3-methyl-(R)-piperidine-1,3-dicarboxylate (934423-10-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

1-(tert-butyl)-3-methyl-(R)-piperidine-1,3-dicarboxylate (934423-10-6) → (R)-3-(hydrazinecarbonyl)piperidine-1-carboxylic acid tert-butyl ester (1002359-83-2)

Guidance literature:

With hydrazine hydrate; at 122 ℃; for 4h;

upstream raw materials:

(R)-1-Boc-nipecotic acid

methyl iodide

di-tert-butyl dicarbonate

(R)-piperidine-3-carboxylic acid methyl ester

Downstream raw materials:

(3R)-3-formylpiperidine-1-carboxylic acid tert-butyl ester

(R)-3-(hydrazinecarbonyl)piperidine-1-carboxylic acid tert-butyl ester

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