2-amino-6-fluoro-3-methylbenzoic acid

Base Information

• Chemical Name: 2-amino-6-fluoro-3-methylbenzoic acid
• CAS No.: 874804-26-9
• Molecular Formula: C₈H₈FNO₂
• Molecular Weight: 169.155
• Mol file: 874804-26-9.mol

Synonyms:2-amino-6-fluoro-3-methylbenzoic acid

Chemical Property of 2-amino-6-fluoro-3-methylbenzoic acid

Chemical Property:

• Boiling Point: 312.8±42.0 °C(Predicted)
• PKA: 4.08±0.10(Predicted)
• PSA: 63.32000
• Density: 1.356±0.06 g/cm3(Predicted)
• LogP: 1.99570
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-6-fluoro-3-methylbenzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-6-fluoro-3-methylbenzoic acid

There total 5 articles about 2-amino-6-fluoro-3-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-7-methylindoline-2,3-dione (668-24-6) → 2-amino-6-fluoro-3-methylbenzoic acid (874804-26-9)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In water; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2015.11.035

Reference yield:

3-fluoro-6-methylaniline (367-29-3) → 2-amino-6-fluoro-3-methylbenzoic acid (874804-26-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; sodium sulfate; hydroxylamine hydrochloride / water / 3 h / 80 °C / Inert atmosphere

2: sulfuric acid / 8 h / 85 °C / Inert atmosphere

3: sodium hydroxide; dihydrogen peroxide / water / 3 h / 80 °C / Inert atmosphere

With hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; sodium sulfate; sodium hydroxide; In water;

DOI:10.1016/j.bmc.2015.11.035

Reference yield:

(2E)-N-(5-fluoro-2-methylphenyl)-2-hydroxyiminoacetamide → 2-amino-6-fluoro-3-methylbenzoic acid (874804-26-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 8 h / 85 °C / Inert atmosphere

2: sodium hydroxide; dihydrogen peroxide / water / 3 h / 80 °C / Inert atmosphere

With sulfuric acid; dihydrogen peroxide; sodium hydroxide; In water;

DOI:10.1016/j.bmc.2015.11.035

upstream raw materials:

3-fluoro-6-methylaniline

4-fluoro-7-methylindoline-2,3-dione

Refernces

• 1、 -. "DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS". . . Retrieved 2016/02/29.