2-Cyclohexylethylboronic acid

Base Information

• Chemical Name: 2-Cyclohexylethylboronic acid
• CAS No.: 167692-95-7
• Molecular Formula: C₁₄H₂₇BO₂
• Molecular Weight: 238.178
• Hs Code.: 2931900090
• Mol file: 167692-95-7.mol

Synonyms:2-Cyclohexylethylboronic acid pinacol ester, 96%

Chemical Property of 2-Cyclohexylethylboronic acid

Chemical Property:

• PSA: 18.46000
• LogP: 4.04900

Purity/Quality:

99%,98%, ^*data from raw suppliers

2-CYCLOHEXYLETHYLBORONIC ACID PINACOL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyclohexylethylboronic acid

There total 27 articles about 2-Cyclohexylethylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

vinylcyclohexane (695-12-5,25498-06-0) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-cyclohexyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethane (167692-95-7)

Guidance literature:

With (^iPrPNN)CoCl₂; sodium triethylborohydride; In tetrahydrofuran; toluene; at 25 ℃; for 0.25h; chemoselective reaction; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1002/anie.201310096

Reference yield: 90.0%

2,3-dimethyl-2,3-butane diol (76-09-5) + 2,2'-bis(1,3,2-benzodioxaborole) (13826-27-2) + 3-chlorobenzoic 3-cyclohexylpropanoic peroxyanhydride → 2-cyclohexyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethane (167692-95-7)

Guidance literature:

2,2'-bis(1,3,2-benzodioxaborole); 3-chlorobenzoic 3-cyclohexylpropanoic peroxyanhydride; With N,N-dimethyl-formamide; at 25 ℃; for 0.333333h; Inert atmosphere;

2,3-dimethyl-2,3-butane diol; With triethylamine; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b04218

Reference yield: 89.0%

ethylidenecyclohexane (1003-64-1) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-cyclohexyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethane (167692-95-7)

Guidance literature:

With (^iPrDI)Co(η³-C₃H₅); In tert-butyl methyl ether; at 23 ℃; for 2h;

DOI:10.1021/cs501639r

upstream raw materials:

2-(1-chloro-2-cyclohexylvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

hydrogen

1-bromo-2-cyclohexylethane

bis(pinacol)diborane

Downstream raw materials:

vinylcyclohexane