N-Boc-4-broMo-3-fluoroaniline

Base Information

• Chemical Name: N-Boc-4-broMo-3-fluoroaniline
• CAS No.: 868735-43-7
• Molecular Formula: C11H13BrFNO2
• Molecular Weight: 290.132
• Hs Code.: 2924299090
• Mol file: 868735-43-7.mol

Synonyms:N-Boc-4-broMo-3-fluoroaniline;(4-Bromo-3-fluoro-phenyl)-carbamic acid tert-butyl ester;tert-butyl N-(4-bromo-3-fluorophenyl)carbamate

Chemical Property of N-Boc-4-broMo-3-fluoroaniline

Chemical Property:

• Melting Point: 68-70℃
• Boiling Point: 274.2±30.0 °C(Predicted)
• PKA: 12.20±0.70(Predicted)
• PSA: 38.33000
• Density: 1.459±0.06 g/cm3(Predicted)
• LogP: 4.00820
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl N-(4-bromo-3-fluorophenyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Boc-4-broMo-3-fluoroaniline

There total 1 articles about N-Boc-4-broMo-3-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-fluoro-4-bromophenylamine (656-65-5) → tert-butyl N-(4-bromo-3-fluorophenyl)carbamate (868735-43-7)

Guidance literature:

In 1,4-dioxane; water; at 80 ℃;

Reference yield: 94.0%

tert-butyl N-(4-bromo-3-fluorophenyl)carbamate (868735-43-7) + bis(pinacol)diborane (73183-34-3) → [3-fluoro-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]carbamic acid tert-butyl ester

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; dimethyl sulfoxide; at 95 ℃; Inert atmosphere;

Reference yield: 69.0%

tert-butyl N-(4-bromo-3-fluorophenyl)carbamate (868735-43-7) + cyclopropylboronic acid (411235-57-9) → tert-butyl (4-cyclopropyl-3-fluorophenyl)carbamate (1255041-91-8)

Guidance literature:

With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 110 ℃; for 20h; Inert atmosphere;

upstream raw materials:

di-tert-butyl dicarbonate

3-fluoro-4-bromophenylamine

Downstream raw materials:

tert-butyl (4-cyclopropyl-3-fluorophenyl)carbamate

(4-((tert-butoxycarbonyl)amino)-2-fluorophenyl)boronic acid

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