DL-Norleucine, N-[(1,1-dimethylethoxy)carbonyl]-

Base Information

• Chemical Name: DL-Norleucine, N-[(1,1-dimethylethoxy)carbonyl]-
• CAS No.: 125342-48-5
• Molecular Formula: C11H21NO4
• Molecular Weight: 231.292
• Hs Code.: 2924190090
• Mol file: 125342-48-5.mol

Synonyms:DL-Norleucine, N-[(1,1-dimethylethoxy)carbonyl]-;Boc-DL-norleucine

Chemical Property of DL-Norleucine, N-[(1,1-dimethylethoxy)carbonyl]-

Chemical Property:

• PSA: 75.63000
• LogP: 2.54540

Purity/Quality:

99% ^*data from raw suppliers

Boc-DL-norleucine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-Norleucine, N-[(1,1-dimethylethoxy)carbonyl]-

There total 4 articles about DL-Norleucine, N-[(1,1-dimethylethoxy)carbonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-hexanoic acid (616-06-8) + di-tert-butyl dicarbonate (24424-99-5) → 2(S)-(tert-Butoxycarbonylamino)hexanoic acid (125342-48-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 0 ℃; for 15.1667h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-aminohexanoic acid (hydrochloride) (70288-84-5) → 2(S)-(tert-Butoxycarbonylamino)hexanoic acid (125342-48-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃;

DOI:10.1021/jacs.1c12350

Reference yield:

1-bromo-butane (109-65-9) + BOC-glycine (4530-20-5) → 2(S)-(tert-Butoxycarbonylamino)hexanoic acid (125342-48-5)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1) THF, 0 deg C, 10 min, 2) 20 deg C, 1 h;

DOI:10.1016/S0040-4039(00)79015-0

upstream raw materials:

1-bromo-butane

BOC-glycine

2-amino-hexanoic acid

di-tert-butyl dicarbonate

Downstream raw materials:

[1-(2-Benzyloxycarbonylamino-ethylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

(+/-)-2-(tert-butoxycarbonyl)-amino-N-[(2,6-dimethyl)phenyl]hexanamide

{1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-pentyl}-carbamic acid tert-butyl ester

(1-formyl-pentyl)-carbamic acid tert-butyl ester

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