Hexadecanoic acid 2,2-dimethyl-1,3-dioxolan-4-ylmethyl ester

Base Information

• Chemical Name: Hexadecanoic acid 2,2-dimethyl-1,3-dioxolan-4-ylmethyl ester
• CAS No.: 18418-21-8
• Molecular Formula: C₂₂H₄₂O₄
• Molecular Weight: 370.573
• Mol file: 18418-21-8.mol

Synonyms:Hexadecanoic acid 2,2-dimethyl-1,3-dioxolan-4-ylmethyl ester;Palmitic acid 2,2-dimethyl-1,3-dioxolan-4-ylmethyl ester

Chemical Property of Hexadecanoic acid 2,2-dimethyl-1,3-dioxolan-4-ylmethyl ester

Chemical Property:

• PSA: 44.76000
• LogP: 6.16240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hexadecanoic acid 2,2-dimethyl-1,3-dioxolan-4-ylmethyl ester

There total 9 articles about Hexadecanoic acid 2,2-dimethyl-1,3-dioxolan-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-hexadecylcarboxylic acid (57-10-3) + (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8,36543-79-0) → 1,2-O-isopropylidene-3-O-palmitoylglycerine (18418-21-8,57416-03-2,115268-48-9,119617-61-7)

Guidance literature:

With toluene-4-sulfonic acid; In neat (no solvent); at 60 ℃; for 4h;

DOI:10.3390/molecules21020170

Reference yield: 93.0%

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8,36543-79-0) + n-hexadecanoyl chloride (112-67-4) → 1,2-O-isopropylidene-3-O-palmitoylglycerine (18418-21-8,57416-03-2,115268-48-9,119617-61-7)

Guidance literature:

With pyridine; dmap; In benzene; at 0 - 10 ℃; for 1h;

DOI:10.1016/j.tet.2012.07.086

Reference yield: 57.0%

hexadecanoic acid methyl ester (112-39-0) + (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8,36543-79-0) → 1,2-O-isopropylidene-3-O-palmitoylglycerine (18418-21-8,57416-03-2,115268-48-9,119617-61-7)

Guidance literature:

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol; With sodium ethanolate; In ethanol;

hexadecanoic acid methyl ester; In ethanol; at 20 - 100 ℃;

DOI:10.1007/s10600-005-0045-7

upstream raw materials:

1-hexadecylcarboxylic acid

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

n-hexadecanoyl chloride

acetone

Downstream raw materials:

C₃₉H₅₂F₆O₈

(+/-)-2,3-di[(E)-2-methyl-2-butenoyloxy]propyl n-hexadecanoate

1-lauroyl-3-palmitoyl-rac-glycerol

1-butyroyl-3-palmitoyl-rac-glycerol