3-Pyrrolidineacetic acid, Methyl ester, hydrochloride, (3R)-

Base Information

• Chemical Name: 3-Pyrrolidineacetic acid, Methyl ester, hydrochloride, (3R)-
• CAS No.: 1024038-31-0
• Molecular Formula: C7H14ClNO2
• Molecular Weight: 179.647
• Mol file: 1024038-31-0.mol

Synonyms:3-Pyrrolidineacetic acid, Methyl ester, hydrochloride, (3R)-;METHYL (R)-PYRROLIDINE-3-ACETATE HCL;methyl 2-[(3R)-pyrrolidin-3-yl]acetate,hydrochloride

Chemical Property of 3-Pyrrolidineacetic acid, Methyl ester, hydrochloride, (3R)-

Chemical Property:

• PSA: 38.33000
• LogP: 1.28980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95-99% ^*data from raw suppliers

Methyl(R)-Pyrrolidine-3-acetateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyrrolidineacetic acid, Methyl ester, hydrochloride, (3R)-

There total 2 articles about 3-Pyrrolidineacetic acid, Methyl ester, hydrochloride, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-methoxycarbonylmethyl-pyrrolidin-1-carboxylic acid tert-butyl ester → (R)-pyrrolidin-3-yl-acetic acid methyl ester hydrochloric acid salt (1024038-31-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

methanol (67-56-1) + (R)-3-carboxymethyl-pyrrolidin-1-carboxylic acid tert-butyl ester (204688-60-8) → (R)-pyrrolidin-3-yl-acetic acid methyl ester hydrochloric acid salt (1024038-31-0)

Guidance literature:

(R)-3-carboxymethyl-pyrrolidin-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 18 - 25 ℃; for 20h;

methanol; With hydrogenchloride; at 10 - 25 ℃;

Reference yield: 58.0%

(R)-pyrrolidin-3-yl-acetic acid methyl ester hydrochloric acid salt (1024038-31-0) + 2-chloro-5-bromofluorobenzene (60811-18-9) → methyl 2-[(3R)-1-(4-chloro-3-fluorophenyl)pyrrolidin-3-yl]acetate

Guidance literature:

With potassium phosphate; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 100 ℃; for 18h; Inert atmosphere; Schlenk technique;

upstream raw materials:

methanol

(R)-3-carboxymethyl-pyrrolidin-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "CHEMICAL COMPOUNDS". Page/Page column 105. . Retrieved 2008/12/04.