(6aR)-10,11-Dimethoxy-4,5,6a,7-tetrahydro-6-methyl-6H-dibenzo[de,g]quinoline

Base Information

• Chemical Name: (6aR)-10,11-Dimethoxy-4,5,6a,7-tetrahydro-6-methyl-6H-dibenzo[de,g]quinoline
• CAS No.: 38291-33-7
• Molecular Formula: C19H21NO2
• Molecular Weight: 295.381
• Mol file: 38291-33-7.mol

Synonyms:(6aR)-10,11-Dimethoxy-4,5,6a,7-tetrahydro-6-methyl-6H-dibenzo[de,g]quinoline;(6aR)-5,6,6a,7-Tetrahydro-10,11-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline

Chemical Property of (6aR)-10,11-Dimethoxy-4,5,6a,7-tetrahydro-6-methyl-6H-dibenzo[de,g]quinoline

Chemical Property:

• PSA: 21.70000
• LogP: 3.39380

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6aR)-10,11-Dimethoxy-4,5,6a,7-tetrahydro-6-methyl-6H-dibenzo[de,g]quinoline

There total 18 articles about (6aR)-10,11-Dimethoxy-4,5,6a,7-tetrahydro-6-methyl-6H-dibenzo[de,g]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + apomorphin (58-00-4) → (R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline (38291-33-7)

Guidance literature:

With potassium hydroxide; In methanol; diethyl ether; at 20 ℃; for 26h;

DOI:10.3987/COM-13-S(S)39

Reference yield: 46.0%

Apocodeine (641-36-1) + methyl iodide (74-88-4) → (R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline (38291-33-7)

Guidance literature:

Apocodeine; With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h;

methyl iodide; In N,N-dimethyl-formamide; for 0.5h;

Reference yield:

10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline (39478-63-2) → (R)-10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline (38291-33-7)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 120 ℃; for 2h;

DOI:10.1016/j.tetasy.2006.08.005

upstream raw materials:

diazomethane

apomorphine hydrochloride

10,11-dimethoxy-6-methyl-5,6-dihydro-4H-dibenzo[de,g]quinoline

10,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

Downstream raw materials:

N-[2-(5,6-dimethoxy-[1]phenanthryl)-ethyl]-N-methyl-benzamide

apomorphin

(S)-(+)-apomorphine hydrochloride

10,11-dimethoxy-6-methyl-6H-dibenzo[de,g]quinoline