5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid

Base Information

Chemical Name:5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid
CAS No.:60424-17-1
Molecular Formula:C14H14O3
Molecular Weight:264.708
Hs Code.:
Mol file:60424-17-1.mol

Synonyms:5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid;rac-5-Chloro Naproxen;Naproxen EP IMpurity B

Suppliers and Price of 5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rac-5-ChloroNaproxen
2.5g
$ 1320.00

TRC
rac-5-ChloroNaproxen
250mg
$ 165.00

Total 5 raw suppliers

Chemical Property of 5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid

Chemical Property:

PSA：46.53000
LogP:3.68990

Purity/Quality:

> 95% ^*data from raw suppliers

rac-5-ChloroNaproxen ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses rac-5-Chloro Naproxen is an impurity of Naproxen (N377526). Naproxen impurity B.

Technology Process of 5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid

There total 9 articles about 5-Chloro-6-Methoxy-α-Methyl-2-naphthaleneacetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 60424-17-1,92471-86-8
2-(5'-chloro-6'-methoxy-2'-naphthyl)-propionic acid

Guidance literature:

Reference yield: 11.0%

: 104483-12-7
α-chloro-1-(5-chloro-6-methoxy-2-naphthyl)propanone

: 60424-17-1,92471-86-8
2-(5'-chloro-6'-methoxy-2'-naphthyl)-propionic acid

: 1-(5-chloro-6-methoxy-2-naphthyl)propan-1-one

: 1-(5-Chloro-6-methoxy-naphthalen-2-yl)-2-hydroxy-propan-1-one

Guidance literature:: With methyloxirane; In water; acetone; Irradiation; pH neutral;
DOI:10.1016/S0040-4020(01)80835-8

Reference yield:

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: 60424-17-1,92471-86-8
2-(5'-chloro-6'-methoxy-2'-naphthyl)-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / Mg / tetrahydrofuran / 4 h / -40 °C

2: 10 percent / propylene oxide / H₂O; acetone / Irradiation; pH neutral

3: 85 percent / SO₂Cl₂ / CCl₄ / 12 h / 50 °C

4: propylene oxide / methanol / Irradiation; pH neutral

5: OH(-)

With sulfuryl dichloride; hydroxide; magnesium; methyloxirane; In tetrahydrofuran; methanol; tetrachloromethane; water; acetone;
DOI:10.1016/S0040-4020(01)80835-8