Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-

Base Information

Chemical Name:Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-
CAS No.:1034305-17-3
Molecular Formula:C15H10BrFS
Molecular Weight:321.213
Hs Code.:
Mol file:1034305-17-3.mol

Synonyms:Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-;2-(5-BroMo-2-fluorobenzyl)benzothiophene;2-(5-BroMo-2-fluorobenzyl)benzo[b]thiophene;2-[(5-bromo-2-fluorophenyl)Methyl]-Benzo[b]thiophene;2-(5-bromo-2-fluorobenzyl)-1-benzothiophene;2-[(5-bromo-2-fluorophenyl)methyl]-1-benzothiophene;Ipragliflozin impurity B (B4);2-[(5-broMo-2-fluorophenyl)Methyl]-

Suppliers and Price of Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
50mg
$ 110.00

TRC
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
100mg
$ 175.00

Crysdot
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene 97%
5g
$ 477.00

Chemenu
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene 95%+
100mg
$ 15.00

Chemenu
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene 95%+
5g
$ 205.00

Chemenu
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene 95%+
250mg
$ 25.00

Chemenu
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene 95%+
1g
$ 57.00

Ambeed
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene 97%
1g
$ 50.00

Ambeed
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene 97%
250mg
$ 22.00

Ambeed
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene 97%
5g
$ 153.00

Total 82 raw suppliers

Chemical Property of Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-

Chemical Property:

Boiling Point:408.9±35.0 °C(Predicted)
PSA：28.24000
Density:1.509±0.06 g/cm3(Predicted)
LogP:5.39370
Storage Temp.:2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-

There total 4 articles about Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.1%

: 1034305-11-7
(1-benzothiophen-2-yl)(5-bromo-2-fluorophenyl)methanol

: 1034305-17-3
2-[(5-bromo-2-fluorophenyl)methyl]-1-benzothiophene

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at -20 ℃; for 0.5h; Solvent;

Reference yield: 80.9%

: 1034305-19-5
2-[(5-bromo-2-fluorophenyl)(chloro)methyl]-1-benzothiophene

: 1034305-17-3
2-[(5-bromo-2-fluorophenyl)methyl]-1-benzothiophene

Guidance literature:: 2-[(5-bromo-2-fluorophenyl)(chloro)methyl]-1-benzothiophene; With sodium tetrahydroborate; sodium hydroxide; In water; acetonitrile; at 40 - 67.9 ℃;

With hydrogenchloride; In water; toluene; acetonitrile; Product distribution / selectivity;

Reference yield:

: 93777-26-5
5-bromo-2-fluorobenzaldehyde

: 1034305-17-3
2-[(5-bromo-2-fluorophenyl)methyl]-1-benzothiophene

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C

1.2: 2 h / -78 °C

2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -20 °C

With triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.bmc.2012.03.051