Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-

Base Information

• Chemical Name: Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-
• CAS No.: 1034305-11-7
• Molecular Formula: C15H10BrFOS
• Molecular Weight: 337.212
• Mol file: 1034305-11-7.mol

Synonyms:Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-;benzo[b]thiophen-2-yl(5-broMo-2-fluorophenyl)Methanol;Ipragliflozin interMdiate;1-benzothien-2-yl(5-bromo-2-fluorophenyl)methanol

Chemical Property of Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-

Chemical Property:

• Boiling Point: 458.7±40.0 °C(Predicted)
• PKA: 12.52±0.20(Predicted)
• PSA: 48.47000
• Density: 1.597±0.06 g/cm3(Predicted)
• LogP: 4.88460
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

α-(5-Bromo-2-fluorophenyl)benzo[b]thiophene-2-methanol, ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)-

There total 2 articles about Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-bromo-2-fluorobenzaldehyde (93777-26-5) + Benzo[b]thiophene (95-15-8,11095-43-5) → (1-benzothiophen-2-yl)(5-bromo-2-fluorophenyl)methanol (1034305-11-7)

Guidance literature:

Benzo[b]thiophene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.5h;

5-bromo-2-fluorobenzaldehyde; In tetrahydrofuran; at -78 ℃; for 2h; Temperature;

Reference yield:

2-bromo-5-fluorobenzaldehyde (94569-84-3) + Benzo[b]thiophene (95-15-8,11095-43-5) → (1-benzothiophen-2-yl)(5-bromo-2-fluorophenyl)methanol (1034305-11-7)

Guidance literature:

Benzo[b]thiophene; With n-butyllithium; In 2-methyltetrahydrofuran; at -40 - 35 ℃; for 3h; Inert atmosphere;

2-bromo-5-fluorobenzaldehyde; In tetrahydrofuran; at -40 - 35 ℃; for 10h; Temperature; Solvent; Reagent/catalyst;

Reference yield: 100.0%

(1-benzothiophen-2-yl)(5-bromo-2-fluorophenyl)methanol (1034305-11-7) → 2-[(5-bromo-2-fluorophenyl)(chloro)methyl]-1-benzothiophene (1034305-19-5)

Guidance literature:

With thionyl chloride; In acetonitrile; at 5 - 25 ℃;

upstream raw materials:

5-bromo-2-fluorobenzaldehyde

Benzo[b]thiophene

2-bromo-5-fluorobenzaldehyde

Downstream raw materials:

2-[(5-bromo-2-fluorophenyl)(chloro)methyl]-1-benzothiophene

[1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane

2-[(5-bromo-2-fluorophenyl)methyl]-1-benzothiophene

(1S)-1,5-anhydro-1-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-2,3,4,6-tetra-O-benzyl - D-glucitol