1-Benzyl-4-broMo-piperidine

Base Information

• Chemical Name: 1-Benzyl-4-broMo-piperidine
• CAS No.: 301665-60-1
• Molecular Formula: C12H16BrN
• Molecular Weight: 254.17
• Hs Code.: 2933399090
• Mol file: 301665-60-1.mol

Synonyms:1-Benzyl-4-broMo-piperidine

Chemical Property of 1-Benzyl-4-broMo-piperidine

Chemical Property:

• Boiling Point: 300.6±35.0 °C(Predicted)
• PKA: 7.31±0.10(Predicted)
• PSA: 3.24000
• Density: 1.336±0.06 g/cm3(Predicted)
• LogP: 2.98380
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

95%, 99% ^*data from raw suppliers

1-Benzyl-4-bromopiperidine >97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyl-4-broMo-piperidine

There total 5 articles about 1-Benzyl-4-broMo-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(1-benzylpiperidin-4-yl)ethyl 4-methylbenzenesulfonate → 1-benzyl-4-bromopiperidine (301665-60-1)

Guidance literature:

With sodium thiosulfate; In ethanol; water; at 110 ℃; for 15h;

Reference yield: 81.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-(1-phenyl-3-butenyl)benzylamine (88381-98-0) → 1-benzyl-4-bromopiperidine (301665-60-1)

Guidance literature:

With zinc dibromide; In water; acetonitrile; at 20 ℃; for 24h;

DOI:10.1002/ejoc.201403607

Reference yield: 53.0%

4-bromopiperidine hydrobromide (54288-70-9) + benzaldehyde (100-52-7) → 1-benzyl-4-bromopiperidine (301665-60-1)

Guidance literature:

4-bromopiperidine hydrobromide; benzaldehyde; With sodium hydrogencarbonate; In methanol; at 20 ℃; for 0.25h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 16h;

DOI:10.1016/j.chempr.2020.04.006

upstream raw materials:

formaldehyd

N-(1-phenyl-3-butenyl)benzylamine

N-benzyl-4-(2-hydroxyethyl)piperidine

4-bromopiperidine hydrobromide

Downstream raw materials:

(1-benzylpiperidin-4-yl)(phenyl)methanone

Refernces

• 1、 Zhang, Wen,Lin, Song. "Electroreductive Carbofunctionalization of Alkenes with Alkyl Bromides via a Radical-Polar Crossover Mechanism". supporting information. p. 20661 - 20670. Retrieved 2020/12/23.
• 2、 Nallasivam, Jothi L.,Fernandes, Rodney A.. "A cascade Aza-Cope/Aza-prins cyclization leading to piperidine derivatives". . p. 2012 - 2022. Retrieved 2015/03/18.