Ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Base Information

• Chemical Name: Ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
• CAS No.: 1399297-47-2
• Molecular Formula: C11H11ClN2O2
• Molecular Weight: 238.67
• Hs Code.: 2933990090
• Mol file: 1399297-47-2.mol

Synonyms:Ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Chemical Property of Ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Chemical Property:

• PSA: 44.12000
• LogP: 2.40340

Purity/Quality:

≥99% ^*data from raw suppliers

Ethyl5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

There total 2 articles about Ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H9ClN2O2 (1083181-28-5) + methyl iodide (74-88-4) → ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (1399297-47-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja305574k

Reference yield:

5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (800401-84-7) → ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (1399297-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / Reflux; Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With thionyl chloride; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/ja305574k

Reference yield:

hydroxy{[(4-methylphenyl)sulfonyl]oxy}-(2,4,6-trimethylphenyl)-λ3–iodine + ethyl 5-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (1399297-47-2) → C27H28ClIN2O5S

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 1h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja502174d

upstream raw materials:

C₁₀H₉ClN₂O₂

methyl iodide

5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid