(4,5,6,7-Tetrahydro-1H-indazol-5-yl)-carbaMic acid tert-butyl ester

Base Information

• Chemical Name: (4,5,6,7-Tetrahydro-1H-indazol-5-yl)-carbaMic acid tert-butyl ester
• CAS No.: 1158767-01-1
• Molecular Formula: C₁₂H₁₉N₃O₂
• Molecular Weight: 237.302
• Mol file: 1158767-01-1.mol

Synonyms:(4,5,6,7-Tetrahydro-1H-indazol-5-yl)-carbaMic acid tert-butyl ester

Chemical Property of (4,5,6,7-Tetrahydro-1H-indazol-5-yl)-carbaMic acid tert-butyl ester

Chemical Property:

• Boiling Point: 432.2±34.0 °C(Predicted)
• PKA: 12.13±0.20(Predicted)
• PSA: 67.01000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 2.18260
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl(4,5,6,7-tetrahydro-1H-indazol-5-yl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4,5,6,7-Tetrahydro-1H-indazol-5-yl)-carbaMic acid tert-butyl ester

There total 2 articles about (4,5,6,7-Tetrahydro-1H-indazol-5-yl)-carbaMic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-dimethylaminomethylene-4-oxo-cyclohexyl)-carbamic acid tert-butyl ester (1171130-67-8) → (+/-)-(4,5,6,7-Tetrahydro-2H-indazol-5-yl)-carbamic acid tert-butyl ester (1158767-01-1,955406-13-0,955406-11-8,955406-14-1)

Guidance literature:

With hydrazine; In ethanol; at 20 ℃;

Reference yield:

N-(tert-butoxycarbonyl)-4-aminocyclohexanone (179321-49-4) → (+/-)-(4,5,6,7-Tetrahydro-2H-indazol-5-yl)-carbamic acid tert-butyl ester (1158767-01-1,955406-13-0,955406-11-8,955406-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 140 °C / Heating / reflux

2: hydrazine / ethanol / 20 °C

With triethylamine; hydrazine; In ethanol;

Reference yield:

(+/-)-(4,5,6,7-Tetrahydro-2H-indazol-5-yl)-carbamic acid tert-butyl ester (1158767-01-1,955406-13-0,955406-11-8,955406-14-1) → (3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one (955407-49-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: methanol; hexanes / Resolution of racemate

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: 1,2-dichloro-ethane; isopropyl alcohol / 17 h / 20 °C

3.2: 2 h / 20 °C

3.3: 1 h / 20 °C

4.1: hydrogen / palladium dihydroxide / ethanol / 6 h / 1551.49 Torr

5.1: pyridine / 4.01 h / 0 - 20 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 17 h / 80 °C

With pyridine; hydrogen; sodium carbonate; trifluoroacetic acid; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; hexanes; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol;

upstream raw materials:

(3-dimethylaminomethylene-4-oxo-cyclohexyl)-carbamic acid tert-butyl ester

N-(tert-butoxycarbonyl)-4-aminocyclohexanone

Downstream raw materials:

(3R,5R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

(3R,5S)-3-(4-hydroxy-2,6-dichloro-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

(3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

(3R,5S)-5-[3-(2,6-dichloro-4-hydroxy-benzyl)-2-oxo-pyrrolidin-1-yl]-4,5,6,7-tetrahydro-indazole-1-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1158767-01-1 (4,5,6,7-Tetrahydro-1H-indazol-5-yl)-carbaMic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send