(3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Base Information

Chemical Name:(3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one
CAS No.:955407-49-5
Molecular Formula:C₂₄H₂₂Cl₂FN₃O
Molecular Weight:458.363
Hs Code.:

Synonyms:(3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Chemical Property of (3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Technology Process of (3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

There total 10 articles about (3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 955406-23-2
(3R,5R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 1765-93-1
4-fluoroboronic acid

: 955407-49-5
(3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 17h;

Reference yield:

: 1171130-67-8
(3-dimethylaminomethylene-4-oxo-cyclohexyl)-carbamic acid tert-butyl ester

: 955407-49-5
(3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrazine / ethanol / 20 °C

2.1: methanol; hexanes / Resolution of racemate

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: 1,2-dichloro-ethane; isopropyl alcohol / 17 h / 20 °C

4.2: 2 h / 20 °C

4.3: 1 h / 20 °C

5.1: hydrogen / palladium dihydroxide / ethanol / 6 h / 1551.49 Torr

6.1: pyridine / 4.01 h / 0 - 20 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 17 h / 80 °C

With pyridine; hydrogen; sodium carbonate; trifluoroacetic acid; hydrazine; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; hexanes; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 955373-73-6
(R)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

: 955407-49-5
(3R,5R)-(+)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,2-dichloro-ethane; isopropyl alcohol / 17 h / 20 °C

1.2: 2 h / 20 °C

1.3: 1 h / 20 °C

2.1: hydrogen / palladium dihydroxide / ethanol / 6 h / 1551.49 Torr

3.1: pyridine / 4.01 h / 0 - 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 17 h / 80 °C

With pyridine; hydrogen; sodium carbonate; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; 1,2-dichloro-ethane; isopropyl alcohol;